8FTM
| Setx-ssRNA-ADP-SO4 complex | Descriptor: | 5'-3' RNA helicase-like protein, ADENOSINE-5'-DIPHOSPHATE, RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3'), ... | Authors: | Williams, R.S, Appel, C.D. | Deposit date: | 2023-01-12 | Release date: | 2023-10-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2. Mol.Cell, 83, 2023
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8FTK
| Chaetomium thermophilum SETX (Full-length) | Descriptor: | 5'-3' RNA helicase-like protein | Authors: | Williams, R.S, Appel, C.D. | Deposit date: | 2023-01-12 | Release date: | 2023-10-25 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (4.56 Å) | Cite: | Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2. Mol.Cell, 83, 2023
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8FTH
| Chaetomium thermophilum SETX - NPPC internal deletion | Descriptor: | 5'-3' RNA helicase-like protein, ADENOSINE-5'-DIPHOSPHATE | Authors: | Williams, R.S, Appel, C.D. | Deposit date: | 2023-01-12 | Release date: | 2023-10-25 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2. Mol.Cell, 83, 2023
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3L41
| Crystal Structure of S. pombe Brc1 BRCT5-BRCT6 domains in complex with phosphorylated H2A | Descriptor: | BRCT-containing protein 1, phosphorylated H2A tail | Authors: | Williams, R.S, Williams, J.S, Guenther, G, Tainer, J.A. | Deposit date: | 2009-12-18 | Release date: | 2010-02-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | gammaH2A binds Brc1 to maintain genome integrity during S-phase. Embo J., 29, 2010
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3L40
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3HUF
| Structure of the S. pombe Nbs1-Ctp1 complex | Descriptor: | DNA repair and telomere maintenance protein nbs1, Double-strand break repair protein ctp1, THIOCYANATE ION | Authors: | Williams, R.S, Guenther, G, Tainer, J.A. | Deposit date: | 2009-06-13 | Release date: | 2009-10-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell(Cambridge,Mass.), 139, 2009
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3DSD
| Crystal structure of P. furiosus Mre11-H85S bound to a branched DNA and manganese | Descriptor: | DNA (5'-D(*DCP*DGP*DCP*DGP*DCP*DAP*DCP*DAP*DAP*DGP*DCP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DGP*DTP*DGP*DGP*DAP*DTP*DA)-3'), DNA double-strand break repair protein mre11, MANGANESE (II) ION | Authors: | Williams, R.S, Moiani, D, Tainer, J.A. | Deposit date: | 2008-07-11 | Release date: | 2008-10-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell(Cambridge,Mass.), 135, 2008
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3DSC
| Crystal structure of P. furiosus Mre11 DNA synaptic complex | Descriptor: | DNA (5'-D(P*DCP*DAP*DCP*DAP*DAP*DGP*DCP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DGP*DTP*DGP*DAP*DC)-3'), DNA double-strand break repair protein mre11 | Authors: | Williams, R.S, Moncalian, G, Shin, D.S, Tainer, J.A. | Deposit date: | 2008-07-11 | Release date: | 2008-10-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell(Cambridge,Mass.), 135, 2008
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3HUE
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1T2V
| Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with phosphopeptide | Descriptor: | BRCTide-7PS, Breast cancer type 1 susceptibility protein | Authors: | Williams, R.S, Lee, M.S, Hau, D.D, Glover, J.N.M. | Deposit date: | 2004-04-22 | Release date: | 2004-05-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1 Nat.Struct.Mol.Biol., 11, 2004
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1T2U
| Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1: structure of BRCA1 missense variant V1809F | Descriptor: | Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION | Authors: | Williams, R.S, Lee, M.S, Duong, D.D, Glover, J.N.M. | Deposit date: | 2004-04-22 | Release date: | 2004-05-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis of Phosphopeptide recognition by the BRCT domain of BRCA1 Nat.Struct.Mol.Biol., 11, 2004
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4CD8
| The structure of GH113 beta-mannanase AaManA from Alicyclobacillus acidocaldarius in complex with ManMIm | Descriptor: | (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, ENDO-BETA-1,4-MANNANASE, beta-D-mannopyranose | Authors: | Williams, R.J, Iglesias-Fernandez, J, Stepper, J, Jackson, A, Thompson, A.J, Lowe, E.C, White, J.M, Gilbert, H.J, Rovira, C, Davies, G.J, Williams, S.J. | Deposit date: | 2013-10-30 | Release date: | 2014-04-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate. Angew.Chem.Int.Ed.Engl., 53, 2014
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4CD5
| The structure of GH26 beta-mannanase CjMan26C from Cellvibrio japonicus in complex with ManMIm | Descriptor: | (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, ENDO-1,4-BETA MANNANASE, PUTATIVE, ... | Authors: | Williams, R.J, Iglesias-Fernandez, J, Stepper, J, Jackson, A, Thompson, A.J, Lowe, E.C, White, J.M, Gilbert, H.J, Rovira, C, Davies, G.J, Williams, S.J. | Deposit date: | 2013-10-30 | Release date: | 2014-04-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate. Angew.Chem.Int.Ed.Engl., 53, 2014
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4CD7
| The structure of GH113 beta-mannanase AaManA from Alicyclobacillus acidocaldarius in complex with ManIFG and beta-1,4-mannobiose | Descriptor: | 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, ENDO-BETA-1,4-MANNANASE, beta-D-mannopyranose, ... | Authors: | Williams, R.J, Iglesias-Fernandez, J, Stepper, J, Jackson, A, Thompson, A.J, Lowe, E.C, White, J.M, Gilbert, H.J, Rovira, C, Davies, G.J, Williams, S.J. | Deposit date: | 2013-10-30 | Release date: | 2014-04-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate. Angew.Chem.Int.Ed.Engl., 53, 2014
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4CD4
| The structure of GH26 beta-mannanase CjMan26C from Cellvibrio japonicus in complex with ManIFG | Descriptor: | 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, ENDO-1,4-BETA MANNANASE, PUTATIVE, ... | Authors: | Williams, R.J, Iglesias-Fernandez, J, Stepper, J, Jackson, A, Thompson, A.J, Lowe, E.C, White, J.M, Gilbert, H.J, Rovira, C, Davies, G.J, Williams, S.J. | Deposit date: | 2013-10-30 | Release date: | 2014-04-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate. Angew.Chem.Int.Ed.Engl., 53, 2014
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4CD6
| The structure of GH113 beta-mannanase AaManA from Alicyclobacillus acidocaldarius in complex with ManIFG | Descriptor: | 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, ENDO-BETA-1,4-MANNANASE, beta-D-mannopyranose | Authors: | Williams, R.J, Iglesias-Fernandez, J, Stepper, J, Jackson, A, Thompson, A.J, Lowe, E.C, White, J.M, Gilbert, H.J, Rovira, C, Davies, G.J, Williams, S.J. | Deposit date: | 2013-10-30 | Release date: | 2014-04-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate. Angew.Chem.Int.Ed.Engl., 53, 2014
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6HL9
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5JDE
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5JDD
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5JDJ
| Crystal structure of domain I10 from titin in space group P212121 | Descriptor: | CALCIUM ION, Titin | Authors: | Williams, R, Bogomolovas, J, Labiet, S, Mayans, O. | Deposit date: | 2016-04-16 | Release date: | 2016-08-17 | Last modified: | 2016-10-12 | Method: | X-RAY DIFFRACTION (1.738 Å) | Cite: | Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. Open Biology, 6, 2016
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2NCK
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1N5O
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1JNX
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5KIV
| Crystal structure of SauMacro (SAV0325) | Descriptor: | 1,2-ETHANEDIOL, ETHANOL, Protein-ADP-ribose hydrolase, ... | Authors: | Williams, R.S, Appel, C.D, Feld, G.K, Wallace, B.D. | Deposit date: | 2016-06-17 | Release date: | 2016-07-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus. Protein Sci., 25, 2016
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1NLK
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