7ESR
 
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8BVO
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8BW6
 | | Titin FnIII-domain I110 (I/A6) from the MIR region | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Mayans, O, Fleming, J.R. | | Deposit date: | 2022-12-06 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-08 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis.
Biomedicines, 11, 2023
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8BXR
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6YP6
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1IDJ
 | | PECTIN LYASE A | | Descriptor: | PECTIN LYASE A | | Authors: | Mayans, O, Scott, M, Connerton, I, Gravesen, T, Benen, J, Visser, J, Pickersgill, R, Jenkins, J. | | Deposit date: | 1996-10-04 | | Release date: | 1997-10-15 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Two crystal structures of pectin lyase A from Aspergillus reveal a pH driven conformational change and striking divergence in the substrate-binding clefts of pectin and pectate lyases.
Structure, 5, 1997
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1IDK
 | | PECTIN LYASE A | | Descriptor: | PECTIN LYASE A | | Authors: | Mayans, O, Scott, M, Connerton, I, Gravesen, T, Benen, J, Visser, J, Pickersgill, R, Jenkins, J. | | Deposit date: | 1996-10-04 | | Release date: | 1997-10-15 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Two crystal structures of pectin lyase A from Aspergillus reveal a pH driven conformational change and striking divergence in the substrate-binding clefts of pectin and pectate lyases.
Structure, 5, 1997
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6FWX
 | | Chimeric titin Z1Z2-Z1Z2 tandem (Z1212) functionalized with a GRGDS exogenous peptide from fibronectin | | Descriptor: | 1,2-ETHANEDIOL, Titin,Titin,Titin | | Authors: | Mayans, O, Fleming, J, Hill, C. | | Deposit date: | 2018-03-07 | | Release date: | 2019-03-27 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Self-Assembling Proteins as High-Performance Substrates for Embryonic Stem Cell Self-Renewal.
Adv. Mater. Weinheim, 31, 2019
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4GSN
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3DDT
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1O17
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4M3L
 | | Crystal Structure of the coiled coil domain of MuRF1 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, E3 ubiquitin-protein ligase TRIM63, ... | | Authors: | Mayans, O, Franke, B. | | Deposit date: | 2013-08-06 | | Release date: | 2014-03-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1.
Open Biol, 4, 2014
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1GXB
 | | ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH PYROPHOSPHATE AND MAGNESIUM | | Descriptor: | ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, PYROPHOSPHATE 2- | | Authors: | Mayans, O, Ivens, A, Nissen, L.J, Kirschner, K, Wilmanns, M. | | Deposit date: | 2002-04-02 | | Release date: | 2003-04-03 | | Last modified: | 2020-03-11 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural Analysis of Two Enzymes Catalysing Reverse Metabolic Reactions Implies Common Ancestry
Embo J., 21, 2002
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1G1C
 | | I1 DOMAIN FROM TITIN | | Descriptor: | IMMUNOGLOBULIN-LIKE DOMAIN I1 FROM TITIN | | Authors: | Mayans, O, Wuerges, J, Gautel, M, Wilmanns, M. | | Deposit date: | 2000-10-11 | | Release date: | 2001-10-12 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural evidence for a possible role of reversible disulphide bridge formation in the elasticity of the muscle protein titin.
Structure, 9, 2001
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8OSP
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7OI1
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7AHS
 | | titin-N2A Ig81-Ig83 | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Isoform 5 of Titin, ... | | Authors: | Fleming, J.R, Mayans, O. | | Deposit date: | 2020-09-25 | | Release date: | 2021-03-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | The N2A region of titin has a unique structural configuration.
J.Gen.Physiol., 153, 2021
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3GBR
 | | Anthranilate phosphoribosyl-transferase (TRPD) double mutant D83G F149S from S. solfataricus | | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Bruning, M, Schlee, S, Deuss, M, Ivens, A, Mayans, O, Sterner, R. | | Deposit date: | 2009-02-20 | | Release date: | 2009-12-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release
Biochemistry, 48, 2009
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8AK3
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8AK2
 | | Drosophila melanogaster UNC89 Protein Kinase Domain 1 (apo) | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Obscurin | | Authors: | Dorendorf, T, Zacharchenko, T, Mayans, O. | | Deposit date: | 2022-07-29 | | Release date: | 2023-03-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | PK1 from Drosophila obscurin is an inactive pseudokinase with scaffolding properties.
Open Biology, 13, 2023
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4JNW
 | | Bacterially expressed Titin Kinase | | Descriptor: | GLYCEROL, Titin | | Authors: | Bogomolovas, J, Labeit, S, Mayans, O. | | Deposit date: | 2013-03-16 | | Release date: | 2014-05-14 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line.
Open Biol, 4, 2014
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5N2P
 | | Sulfolobus solfataricus Tryptophan Synthase A | | Descriptor: | CHLORIDE ION, TETRAETHYLENE GLYCOL, Tryptophan synthase alpha chain | | Authors: | Fleming, J, Mayans, O. | | Deposit date: | 2017-02-08 | | Release date: | 2018-06-13 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.059 Å) | | Cite: | Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole.
J.Mol.Biol., 430, 2018
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6SDB
 | | Chimeric titin Z1Z2 functionalized with a KLER exogenous peptide from decorin | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, PHOSPHATE ION, ... | | Authors: | Fleming, J.R, Hill, C, Mayans, O.M. | | Deposit date: | 2019-07-26 | | Release date: | 2019-09-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The ZT Biopolymer: A Self-Assembling Protein Scaffold for Stem Cell Applications.
Int J Mol Sci, 20, 2019
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8BNQ
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3LPW
 | | Crystal structure of the FnIII-tandem A77-A78 from the A-band of titin | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, A77-A78 domain from Titin | | Authors: | Bucher, R.M, Mayans, O. | | Deposit date: | 2010-02-06 | | Release date: | 2010-09-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The structure of the FnIII Tandem A77-A78 points to a periodically conserved architecture in the myosin-binding region of titin
J.Mol.Biol., 401, 2010
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