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PDB: 30 results

4MYC
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BU of 4myc by Molmil
Structure of the mitochondrial ABC transporter, Atm1
Descriptor: Iron-sulfur clusters transporter ATM1, mitochondrial
Authors:Srinivasan, V.
Deposit date:2013-09-27
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1.
Science, 343, 2014
6GEM
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BU of 6gem by Molmil
FeII-Dependent Halogenase Wi-WelO15
Descriptor: 2-OXOGLUTARIC ACID, FE (III) ION, Oxidoreductase
Authors:Srinivasan, V.
Deposit date:2018-04-26
Release date:2019-05-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.462 Å)
Cite:Directed Evolution of an FeII-Dependent Halogenase for Asymmetric C(sp3)-H Chlorination
ChemRxiv, 2019
5M23
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Modulation of MLL1 Methyltransferase Activity
Descriptor: 4-[(~{E})-[4-[[[(2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-pentanoyl]amino]propanoyl]amino]methyl]phenyl]diazenyl]-~{N}-[(2~{S})-3-methyl-1-oxidanylidene-butan-2-yl]benzamide, WD repeat-containing protein 5
Authors:Srinivasan, V.
Deposit date:2016-10-11
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia.
Chem Sci, 8, 2017
8OZB
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BU of 8ozb by Molmil
Crystal structure of Nup35-Nb complex
Descriptor: Nucleoporin NUP35, Nup35 nanobody
Authors:Srinivasan, V.
Deposit date:2023-05-08
Release date:2024-02-28
Last modified:2024-06-12
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:A checkpoint function for Nup98 in nuclear pore formation suggested by novel inhibitory nanobodies.
Embo J., 43, 2024
2HES
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BU of 2hes by Molmil
Cytosolic Iron-sulphur Assembly Protein- 1
Descriptor: CALCIUM ION, Ydr267cp
Authors:Srinivasan, V, Michel, H, Lill, R, Daili, J.A.N, Pierik, A.J.
Deposit date:2006-06-22
Release date:2007-07-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the Yeast WD40 Domain Protein Cia1, a Component Acting Late in Iron-Sulfur Protein Biogenesis.
Structure, 15, 2007
7OFT
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BU of 7oft by Molmil
Structure of SARS-CoV-2 Papain-like protease PLpro in complex with p-hydroxybenzaldehyde
Descriptor: CHLORIDE ION, P-HYDROXYBENZALDEHYDE, POTASSIUM ION, ...
Authors:Srinivasan, V, Werner, N, Falke, S, Guenther, S, Reinke, P, Brognaro, H, Ullah, N, Andaleeb, H, Perbandt, M, Alves Franca, B, Schwinzer, M, Wang, M, Ewert, W, Sprenger, J, Lieske, J, Koua, F, Ginn, H, Lane, T.J, Wolf, M, Yefanov, O, Gelisio, L, Saouane, S, Tolstikova, A, Groessler, M, Fleckenstein, H, Trost, F, Lorenzen, K, Schubert, R, Han, H, Schmidt, C, Brings, L, Galchenkova, M, Gevorkov, Y, Li, C, Perk, A, Awel, S, Wahab, A, Choudary, I, Turk, D, Hinrichs, W, Chapman, H.N, Meents, A, Betzel, C.
Deposit date:2021-05-05
Release date:2021-05-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.
Commun Biol, 5, 2022
7OFS
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BU of 7ofs by Molmil
Structure of SARS-CoV-2 Papain-like protease PLpro in complex with 4-(2-hydroxyethyl)phenol
Descriptor: 4-(2-hydroxyethyl)phenol, CHLORIDE ION, GLYCEROL, ...
Authors:Srinivasan, V, Werner, N, Falke, S, Guenther, S, Reinke, P, Ewert, W, Sprenger, J, Koua, F, Brognaro, H, Ullah, N, Andaleeb, H, Perbandt, M, Alves Franca, B, Schwinzer, M, Wang, M, Lieske, J, Ginn, H, Lane, T.J, Yefanov, O, Gelisio, L, Hakanpaeae, J, Saouane, S, Tolstikova, A, Groessler, M, Fleckenstein, H, Trost, F, Wolf, M, Lorenzen, K, Schubert, R, Han, H, Schmidt, C, Brings, L, Galchenkova, M, Gevorkov, Y, Li, C, Perk, A, Awel, S, Wahab, A, Choudary, I, Turk, D, Hinrichs, W, Chapman, H.N, Meents, A, Betzel, C.
Deposit date:2021-05-05
Release date:2021-05-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.
Commun Biol, 5, 2022
7OFU
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BU of 7ofu by Molmil
Structure of SARS-CoV-2 Papain-like protease PLpro in complex with 3, 4-Dihydroxybenzoic acid, methyl ester
Descriptor: CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ...
Authors:Srinivasan, V, Ewert, W, Werner, N, Falke, S, Guenther, S, Reinke, P, Sprenger, J, Brognaro, H, Ullah, N, Andaleeb, H, Perbandt, M, Alves Franca, B, Schwinzer, M, Wang, M, Wolf, M, Lieske, J, Koua, F, Ginn, H, Lane, T.J, Yefanov, O, Gelisio, L, Hakanpaeae, J, Saouane, S, Tolstikova, A, Groessler, M, Fleckenstein, H, Trost, F, Lorenzen, K, Schubert, R, Han, H, Schmidt, C, Brings, L, Galchenkova, M, Gevorkov, Y, Li, C, Perk, A, Awel, S, Wahab, A, Choudary, I, Turk, D, Hinrichs, W, Chapman, H.N, Meents, A, Betzel, C.
Deposit date:2021-05-05
Release date:2021-05-12
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.
Commun Biol, 5, 2022
1W2L
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BU of 1w2l by Molmil
Cytochrome c domain of caa3 oxygen oxidoreductase
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CYTOCHROME OXIDASE SUBUNIT II, ...
Authors:Srinivasan, V, Rajendran, C, Sousa, F.L, Melo, A.M.P, Saraiva, L.M, Pereira, M.M, Santana, M, Teixeira, M, Michel, H.
Deposit date:2004-07-06
Release date:2005-01-19
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure at 1.3 A resolution of Rhodothermus marinus caa(3) cytochrome c domain.
J. Mol. Biol., 345, 2005
4MYH
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BU of 4myh by Molmil
Structure of the Glutathione bound mitochondrial ABC transporter, Atm1
Descriptor: GLUTATHIONE, Iron-sulfur clusters transporter ATM1, mitochondrial
Authors:Srinivasan, V.
Deposit date:2013-09-27
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1.
Science, 343, 2014
7NFV
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BU of 7nfv by Molmil
Structure of SARS-CoV-2 Papain-like protease PLpro
Descriptor: CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ...
Authors:Srinivasan, V, Gunther, S, Reinke, P, Werner, N, Falke, S, Brognaro, H, Ullah, N, Andaleeb, H, Perbandt, M, Alves Franca, B, Schwinzer, M, Wang, M, Sprenger, J, Lieske, J, Ginn, H, Lane, T.J, Yefanov, O, Gelisio, L, Koua, F, Saouane, S, Tolstikova, A, Groessler, M, Fleckenstein, H, Ewert, W, Trost, F, Lorenzen, K, Schubert, R, Han, H, Schmidt, C, Brings, L, Ehrt, C, Rarey, M, Galchenkova, M, Gevorkov, Y, Li, C, Perk, A, Awel, S, Hinrichs, W, Meents, A, Betzel, C.
Deposit date:2021-02-07
Release date:2021-02-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.
Commun Biol, 5, 2022
5M25
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BU of 5m25 by Molmil
Modulation of MLL1 Methyltransferase Activity
Descriptor: (2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-~{N}-[(2~{S})-1-[[4-[(~{E})-[4-(hydroxymethyl)phenyl]diazenyl]phenyl]methylamino]-1-oxidanylidene-propan-2-yl]pentanamide, WD repeat-containing protein 5
Authors:Srinivasan, V.
Deposit date:2016-10-11
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia.
Chem Sci, 8, 2017
3BYR
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BU of 3byr by Molmil
Mode of Action of a Putative Zinc Transporter CzrB (Zn form)
Descriptor: CzrB protein, ZINC ION
Authors:Cherezov, V, Srinivasan, V, Szebenyi, D.M.E, Caffrey, M.
Deposit date:2008-01-16
Release date:2008-09-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into the Mode of Action of a Putative Zinc Transporter CzrB in Thermus thermophilus
Structure, 16, 2008
3BYP
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BU of 3byp by Molmil
Mode of Action of a Putative Zinc Transporter CzrB
Descriptor: CzrB protein, SULFATE ION
Authors:Cherezov, V, Srinivasan, V, Szebenyi, D.M.E, Caffrey, M.
Deposit date:2008-01-16
Release date:2008-09-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights into the Mode of Action of a Putative Zinc Transporter CzrB in Thermus thermophilus
Structure, 16, 2008
2X1P
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BU of 2x1p by Molmil
Gelsolin Nanobody
Descriptor: GELSOLIN NANOBODY
Authors:Van Den Abbeele, A, Declercq, S, De Ganck, A, De Corte, V, Van Loo, B, Srinivasan, V, Steyaert, J, Van De Kerckhove, J, Gettemans, J.
Deposit date:2010-01-03
Release date:2011-01-12
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:A Llama-Derived Gelsolin Single-Domain Antibody Blocks Gelsolin-G-Actin Interaction.
Cell.Mol.Life Sci., 67, 2010
2X1Q
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BU of 2x1q by Molmil
Gelsolin Nanobody
Descriptor: GELSOLIN NANOBODY
Authors:Van Den Abbeele, A, Declercq, S, De Ganck, A, De Corte, V, Van Loo, B, Srinivasan, V, Steyaert, J, Van De Kerckhove, J, Gettemans, J.
Deposit date:2010-01-03
Release date:2011-01-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:A Llama-Derived Gelsolin Single-Domain Antibody Blocks Gelsolin-G-Actin Interaction.
Cell.Mol.Life Sci., 67, 2010
2X89
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BU of 2x89 by Molmil
Structure of the Beta2_microglobulin involved in amyloidogenesis
Descriptor: ANTIBODY, BETA-2-MICROGLOBULIN
Authors:Domanska, K, Srinivasan, V, Vanderhaegen, S, Pardon, E, Marquez, J.A, Bellotti, V, Wyns, L, Steyaert, J.
Deposit date:2010-03-07
Release date:2011-01-19
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Atomic Structure of a Nanobody-Trapped Domain-Swapped Dimer of an Amyloidogenic {Beta}2-Microglobulin Variant.
Proc.Natl.Acad.Sci.USA, 108, 2011
2X1O
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BU of 2x1o by Molmil
Gelsolin Nanobody
Descriptor: GELSOLIN NANOBODY
Authors:Van Den Abbeele, A, Declercq, S, De Ganck, A, De Corte, V, Van Loo, B, Srinivasan, V, Steyaert, J, Van De Kerckhove, J, Gettemans, J.
Deposit date:2010-01-03
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:A Llama-Derived Gelsolin Single-Domain Antibody Blocks Gelsolin-G-Actin Interaction.
Cell.Mol.Life Sci., 67, 2010
4EIG
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BU of 4eig by Molmil
CA1698 camel antibody fragment in complex with DHFR
Descriptor: CA1698 camel antibody fragment, Dihydrofolate reductase
Authors:Oyen, D, Srinivasan, V.
Deposit date:2012-04-05
Release date:2013-04-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
3K74
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Disruption of protein dynamics by an allosteric effector antibody
Descriptor: Dihydrofolate reductase, Nanobody
Authors:Oyen, D, Srinivasan, V, Steyaert, J, Barlow, J.
Deposit date:2009-10-12
Release date:2010-10-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.
J.Mol.Biol., 407, 2011
4EIZ
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BU of 4eiz by Molmil
Structure of Nb113 bound to apoDHFR
Descriptor: Dihydrofolate reductase, Nb113 Camel antibody fragment
Authors:Oyen, D, Srinivasan, V.
Deposit date:2012-04-06
Release date:2013-04-24
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4EJ1
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BU of 4ej1 by Molmil
Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex
Descriptor: Dihydrofolate reductase, FOLIC ACID, Nb113 camelid antibody fragment, ...
Authors:Oyen, D, Srinivasan, V.
Deposit date:2012-04-06
Release date:2013-04-24
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
7PXZ
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BU of 7pxz by Molmil
Reduced form of SARS-CoV-2 Main Protease determined by XFEL radiation
Descriptor: 3C-like proteinase nsp5, CHLORIDE ION
Authors:Schubert, R, Reinke, P, Galchenkova, M, Oberthuer, D, Murillo, G.E.P, Kim, C, Bean, R, Turk, D, Hinrichs, W, Middendorf, P, Round, A, Schmidt, C, Mills, G, Kirkwood, H, Han, H, Koliyadu, J, Bielecki, J, Gelisio, L, Sikorski, M, Kloos, M, Vakilii, M, Yefanov, O.N, Vagovic, P, de-Wijn, R, Letrun, R, Guenther, S, White, T.A, Sato, T, Srinivasan, V, Kim, Y, Chretien, A, Han, S, Brognaro, H, Maracke, J, Knoska, J, Seychell, B.C, Brings, L, Norton-Baker, B, Geng, T, Dore, A.S, Uetrecht, C, Redecke, L, Beck, T, Lorenzen, K, Betzel, C, Mancuso, A.P, Bajt, S, Chapman, H.N, Meents, A, Lane, T.J.
Deposit date:2021-10-08
Release date:2023-01-18
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:SARS-CoV-2 M pro responds to oxidation by forming disulfide and NOS/SONOS bonds.
Nat Commun, 15, 2024
7PZQ
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Oxidized form of SARS-CoV-2 Main Protease determined by XFEL radiation
Descriptor: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE
Authors:Schubert, R, Reinke, P, Galchenkova, M, Oberthuer, D, Murillo, G.E.P, Kim, C, Bean, R, Turk, D, Hinrichs, W, Middendorf, P, Round, A, Schmidt, C, Mills, G, Kirkwood, H, Han, H, Koliyadu, J, Bielecki, J, Gelisio, L, Sikorski, M, Kloos, M, Vakilii, M, Yefanov, O.N, Vagovic, P, de-Wijn, R, Letrun, R, Guenther, S, White, T.A, Sato, T, Srinivasan, V, Kim, Y, Chretien, A, Han, S, Brognaro, H, Maracke, J, Knoska, J, Seychell, B.C, Brings, L, Norton-Baker, B, Geng, T, Dore, A.S, Uetrecht, C, Redecke, L, Beck, T, Lorenzen, K, Betzel, C, Mancuso, A.P, Bajt, S, Chapman, H.N, Meents, A, Lane, T.J.
Deposit date:2021-10-13
Release date:2023-01-25
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:SARS-CoV-2 M pro responds to oxidation by forming disulfide and NOS/SONOS bonds.
Nat Commun, 15, 2024
7QCM
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Structure of SARS-CoV-2 Papain-like Protease bound to N-(3-methoxy-4-hydroxy-acetophenone)thiosemicarbazone
Descriptor: CHLORIDE ION, GLYCEROL, N-(3-metoxy-4-hydroxy-acetophenone)thiosemicarbazone, ...
Authors:Ewert, W, Gunther, S, Reinke, P, Falke, S, Lieske, J, Miglioli, F, Carcelli, M, Srinivasan, V, Betzel, C, Han, H, Lorenzen, K, Guenther, C, Niebling, S, Garcia-Alai, M, Hinrichs, W, Rogolino, D, Meents, A.
Deposit date:2021-11-24
Release date:2022-03-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease.
Front Chem, 10, 2022

 

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