1BUP
| T13S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Sousa, M.C, Mckay, D.B. | Deposit date: | 1998-09-03 | Release date: | 1998-09-09 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The hydroxyl of threonine 13 of the bovine 70-kDa heat shock cognate protein is essential for transducing the ATP-induced conformational change. Biochemistry, 37, 1998
|
|
8FTN
| E. coli ArnA dehydrogenase domain mutant - N492A | Descriptor: | Bifunctional UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronic acid oxidase ArnA, SULFATE ION | Authors: | Sousa, M.C, Mitchell, M.E. | Deposit date: | 2023-01-12 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Targeting the Conformational Change in ArnA Dehydrogenase for Selective Inhibition of Polymyxin Resistance. Biochemistry, 62, 2023
|
|
8GJH
| Salmonella ArnA | Descriptor: | Bifunctional polymyxin resistance protein ArnA, URIDINE-5'-DIPHOSPHATE-GLUCURONIC ACID | Authors: | Sousa, M.C, Mitchell, M.E, Gatzeva-Topalova, P.Z. | Deposit date: | 2023-03-15 | Release date: | 2023-08-02 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Targeting the Conformational Change in ArnA Dehydrogenase for Selective Inhibition of Polymyxin Resistance. Biochemistry, 62, 2023
|
|
8T0J
| Salmonella Typhimurium ArnD | Descriptor: | Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD | Authors: | Sousa, M.C, Munoz-Escudero, D, Lee, M. | Deposit date: | 2023-06-01 | Release date: | 2023-10-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structure and Function of ArnD. A Deformylase Essential for Lipid A Modification with 4-Amino-4-deoxy-l-arabinose and Polymyxin Resistance. Biochemistry, 62, 2023
|
|
1KYI
| HslUV (H. influenzae)-NLVS Vinyl Sulfone Inhibitor Complex | Descriptor: | 4-IODO-3-NITROPHENYL ACETYL-LEUCINYL-LEUCINYL-LEUCINYL-VINYLSULFONE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent hsl protease ATP-binding subunit hslU, ... | Authors: | Sousa, M.C, Kessler, B.M, Overkleeft, H.S, McKay, D.B. | Deposit date: | 2002-02-04 | Release date: | 2002-05-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal Structure of HslUV Complexed with a Vinyl Sulfone Inhibitor:
Corroboration of a Proposed Mechanism of Allosteric Activation of
HslV by HslU J.Mol.Biol., 318, 2002
|
|
4LDR
| Structure of the S283Y mutant of MRDI | Descriptor: | Methylthioribose-1-phosphate isomerase | Authors: | Sousa, M.C, Templeton, P.D, Metzner, S.I. | Deposit date: | 2013-06-25 | Release date: | 2013-07-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.292 Å) | Cite: | Structure of Mediator of RhoA-Dependent Invasion (MRDI) Explains Its Dual Function as a Metabolic Enzyme and a Mediator of Cell Invasion. Biochemistry, 52, 2013
|
|
4LDQ
| |
2BUP
| T13G Mutant of the ATPASE fragment of Bovine HSC70 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | Authors: | Sousa, M.C, Mckay, D.B. | Deposit date: | 1998-09-08 | Release date: | 1998-09-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The hydroxyl of threonine 13 of the bovine 70-kDa heat shock cognate protein is essential for transducing the ATP-induced conformational change. Biochemistry, 37, 1998
|
|
4OCA
| Cryatal structure of ArnB K188A complexted with PLP and UDP-Ara4N | Descriptor: | (2R,3R,4S,5S)-3,4-dihydroxy-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]tetrahydro-2H-pyr an-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase | Authors: | Sousa, M.C, Lee, M. | Deposit date: | 2014-01-08 | Release date: | 2014-03-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis for Substrate Specificity in ArnB. A Key Enzyme in the Polymyxin Resistance Pathway of Gram-Negative Bacteria. Biochemistry, 53, 2014
|
|
1JJW
| |
1JMV
| |
4Q3J
| Crystal structure of NFkB-p65-degrading zinc protease family protein | Descriptor: | MAGNESIUM ION, NFkB-p65-degrading zinc protease family protein, ZINC ION | Authors: | Sousa, M.C, Turco, M.M. | Deposit date: | 2014-04-11 | Release date: | 2014-07-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.862 Å) | Cite: | The Structure and Specificity of the Type III Secretion System Effector NleC Suggest a DNA Mimicry Mechanism of Substrate Recognition. Biochemistry, 53, 2014
|
|
1G3K
| |
1G3I
| CRYSTAL STRUCTURE OF THE HSLUV PROTEASE-CHAPERONE COMPLEX | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-DEPENDENT HSLU PROTEASE ATP-BINDING SUBUNIT HSLU, ATP-DEPENDENT PROTEASE HSLV | Authors: | Sousa, M.C, Trame, C.B, Tsuruta, H, Wilbanks, S.M, Reddy, V.S, McKay, D.B. | Deposit date: | 2000-10-24 | Release date: | 2000-11-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | Crystal and solution structures of an HslUV protease-chaperone complex. Cell(Cambridge,Mass.), 103, 2000
|
|
1U2M
| Crystal Structure of Skp | Descriptor: | Histone-like protein HLP-1 | Authors: | Walton, T.A, Sousa, M.C. | Deposit date: | 2004-07-19 | Release date: | 2004-08-24 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of Skp, a Prefoldin-like Chaperone that Protects Soluble and Membrane Proteins from Aggregation Mol.Cell, 15, 2004
|
|
1U9J
| |
4PK1
| Structure of BamB fused to a BamA POTRA domain fragment | Descriptor: | Chimera protein of Outer membrane protein assembly factors BamA and BamB | Authors: | Jansen, K.B, Sousa, M.C. | Deposit date: | 2014-05-13 | Release date: | 2014-12-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal Structure of BamB Bound to a Periplasmic Domain Fragment of BamA, the Central Component of the beta-Barrel Assembly Machine. J.Biol.Chem., 290, 2015
|
|
3EFC
| |
5CT9
| G158E/K44E/R57E/Y49E Bacillus subtilis lipase A with 5% [BMIM][Cl] | Descriptor: | 1-butyl-3-methyl-1H-imidazol-3-ium, CHLORIDE ION, Esterase | Authors: | Nordwald, E.M, Plaks, J.G, Snell, J.R, Sousa, M.C, Kaar, J.L. | Deposit date: | 2015-07-23 | Release date: | 2015-11-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Enzyme Structure. Chembiochem, 16, 2015
|
|
5CTA
| G158E/K44E/R57E/Y49E Bacillus subtilis lipase A with 10% [BMIM][Cl] | Descriptor: | 1-butyl-3-methyl-1H-imidazol-3-ium, CHLORIDE ION, Esterase | Authors: | Nordwald, E.M, Plaks, J.G, Snell, J.R, Sousa, M.C, Kaar, J.L. | Deposit date: | 2015-07-23 | Release date: | 2015-11-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Enzyme Structure. Chembiochem, 16, 2015
|
|
5EFR
| |
5CRI
| Wild-type Bacillus subtilis lipase A with 0% [BMIM][Cl] | Descriptor: | Esterase, SULFATE ION | Authors: | Nordwald, E.M, Plaks, J.G, Snell, J.R, Sousa, M.C, Kaar, J.L. | Deposit date: | 2015-07-22 | Release date: | 2015-11-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Enzyme Structure. Chembiochem, 16, 2015
|
|
5CT6
| Wild-type Bacillus subtilis lipase A with 20% [BMIM][Cl] | Descriptor: | 1-butyl-3-methyl-1H-imidazol-3-ium, CHLORIDE ION, Lipase EstA | Authors: | Nordwald, E.M, Plaks, J.G, Snell, J.R, Sousa, M.C, Kaar, J.L. | Deposit date: | 2015-07-23 | Release date: | 2015-11-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Enzyme Structure. Chembiochem, 16, 2015
|
|
5CT8
| G158E/K44E/R57E/Y49E Bacillus subtilis lipase A with 0% [BMIM][Cl] | Descriptor: | Quadruple mutant lipase A, SULFATE ION | Authors: | Nordwald, E.M, Plaks, J.G, Snell, J.R, Sousa, M.C, Kaar, J.L. | Deposit date: | 2015-07-23 | Release date: | 2015-11-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Enzyme Structure. Chembiochem, 16, 2015
|
|
5CT4
| Wild-type Bacillus subtilis lipase A with 5% [BMIM][Cl] | Descriptor: | 1-butyl-3-methyl-1H-imidazol-3-ium, CHLORIDE ION, Esterase, ... | Authors: | Nordwald, E.M, Plaks, J.G, Snell, J.R, Sousa, M.C, Kaar, J.L. | Deposit date: | 2015-07-23 | Release date: | 2015-11-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Enzyme Structure. Chembiochem, 16, 2015
|
|