4EHR
| Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide | Descriptor: | 4-[5-butyl-3-(hydroxymethyl)-1-phenyl-1H-pyrazol-4-yl]-3-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}benzamide, Bcl-2-like protein 1, IMIDAZOLE | Authors: | Schroeder, G.M, Wei, D, Banfi, P, Cai, Z, Lippy, J, Menichincheri, M, Modugno, M, Naglich, J, Penhallow, B, Perez, H.L, Sack, J, Schmidt, R.J, Tebben, A, Yan, C, Zhang, L, Galvani, A, Lombardo, L.J, Borzilleri, R.M. | Deposit date: | 2012-04-03 | Release date: | 2012-06-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists. Bioorg.Med.Chem.Lett., 22, 2012
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8FB3
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5HD7
| Dissecting Therapeutic Resistance to ERK Inhibition Rat Mutant SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide | Descriptor: | (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Jha, S, Morris, E.J, Hruza, A, Mansueto, M.S, Schroeder, G, Arbanas, J, McMasters, D, Restaino, C.R, Dayananth, R, Black, S, Elsen, N.L, Mannarino, A, Cooper, A, Fawell, S, Zawel, L, Jayaraman, L, Samatar, A.A. | Deposit date: | 2016-01-04 | Release date: | 2016-02-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Dissecting Therapeutic Resistance to ERK Inhibition. Mol.Cancer Ther., 15, 2016
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5HD4
| Dissecting Therapeutic Resistance to ERK Inhibition Rat Wild Type SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide | Descriptor: | (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | Authors: | Jha, S, Morris, E.J, Hruza, A, Mansueto, M.S, Schroeder, G, Arbanas, J, McMasters, D, Restaino, C.R, Dayananth, R, Black, S, Elsen, N.L, Mannarino, A, Cooper, A, Fawell, S, Zawel, L, Jayaraman, L, Samatar, A.A. | Deposit date: | 2016-01-04 | Release date: | 2016-02-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Dissecting Therapeutic Resistance to ERK Inhibition. Mol.Cancer Ther., 15, 2016
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8FZA
| Class I type III preQ1 riboswitch from E. coli | Descriptor: | 7-DEAZA-7-AMINOMETHYL-GUANINE, MANGANESE (II) ION, PreQ1 Riboswitch (30-MER) | Authors: | Wedekind, J.E, Schroeder, G.M, Jenkins, J.L. | Deposit date: | 2023-01-27 | Release date: | 2023-08-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and function analysis of a type III preQ 1 -I riboswitch from Escherichia coli reveals direct metabolite sensing by the Shine-Dalgarno sequence. J.Biol.Chem., 299, 2023
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7Q64
| Cryo-em structure of the Nup98 fibril polymorph 1 | Descriptor: | Nuclear pore complex protein Nup98 | Authors: | Ibanez de Opakua, A, Geraets, J.A, Frieg, B, Dienemann, C, Savastano, A, Rankovic, M, Cima-Omori, M.-S, Schroeder, G.F, Zweckstetter, M. | Deposit date: | 2021-11-05 | Release date: | 2022-10-12 | Last modified: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Molecular interactions of FG nucleoporin repeats at high resolution. Nat.Chem., 14, 2022
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2P0U
| crystal structure of Marchantia polymorpha stilbenecarboxylate synthase 2 (STCS2) | Descriptor: | GLYCEROL, NICKEL (II) ION, SULFATE ION, ... | Authors: | Borel, F, Schroeder, G, Schroeder, J, Ferrer, J.-L. | Deposit date: | 2007-03-01 | Release date: | 2007-03-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | crystal structure of Marchantia polymorpha stilbenecarboxylate synthase 2 (STCS2) To be Published
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7REX
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7Q65
| Cryo-em structure of the Nup98 fibril polymorph 2 | Descriptor: | Nuclear pore complex protein Nup98 | Authors: | Ibanez de Opakua, A, Geraets, J.A, Frieg, B, Dienemann, C, Savastano, A, Rankovic, M, Cima-Omori, M.-S, Schroeder, G.F, Zweckstetter, M. | Deposit date: | 2021-11-05 | Release date: | 2022-10-12 | Last modified: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Molecular interactions of FG nucleoporin repeats at high resolution. Nat.Chem., 14, 2022
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7Q67
| Cryo-em structure of the Nup98 fibril polymorph 4 | Descriptor: | Nuclear pore complex protein Nup98 | Authors: | Ibanez de Opakua, A, Geraets, J.A, Frieg, B, Dienemann, C, Savastano, A, Rankovic, M, Cima-Omori, M.-S, Schroeder, G.F, Zweckstetter, M. | Deposit date: | 2021-11-05 | Release date: | 2022-10-12 | Last modified: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Molecular interactions of FG nucleoporin repeats at high resolution. Nat.Chem., 14, 2022
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7Q66
| Cryo-em structure of the Nup98 fibril polymorph 3 | Descriptor: | Nuclear pore complex protein Nup98 | Authors: | Ibanez de Opakua, A, Geraets, J.A, Frieg, B, Dienemann, C, Savastano, A, Rankovic, M, Cima-Omori, M.-S, Schroeder, G.F, Zweckstetter, M. | Deposit date: | 2021-11-05 | Release date: | 2022-10-12 | Last modified: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Molecular interactions of FG nucleoporin repeats at high resolution. Nat.Chem., 14, 2022
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7OZG
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7OZH
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8A4L
| Lipidic alpha-synuclein fibril - polymorph L2A | Descriptor: | Alpha-synuclein | Authors: | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | Deposit date: | 2022-06-12 | Release date: | 2022-08-17 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | The 3D structure of lipidic fibrils of alpha-synuclein. Nat Commun, 13, 2022
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8ADS
| Lipidic alpha-synuclein fibril - polymorph L2B | Descriptor: | Alpha-synuclein | Authors: | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | Deposit date: | 2022-07-11 | Release date: | 2022-10-12 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | The 3D structure of lipidic fibrils of alpha-synuclein. Nat Commun, 13, 2022
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8ADV
| Lipidic alpha-synuclein fibril - polymorph L1B | Descriptor: | Alpha-synuclein | Authors: | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | Deposit date: | 2022-07-11 | Release date: | 2022-10-12 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | The 3D structure of lipidic fibrils of alpha-synuclein. Nat Commun, 13, 2022
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8AEX
| Lipidic alpha-synuclein fibril - polymorph L3A | Descriptor: | Alpha-synuclein | Authors: | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | Deposit date: | 2022-07-14 | Release date: | 2022-10-12 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | The 3D structure of lipidic fibrils of alpha-synuclein. Nat Commun, 13, 2022
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8ADW
| Lipidic alpha-synuclein fibril - polymorph L1C | Descriptor: | Alpha-synuclein | Authors: | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | Deposit date: | 2022-07-11 | Release date: | 2022-10-12 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | The 3D structure of lipidic fibrils of alpha-synuclein. Nat Commun, 13, 2022
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8ADU
| Lipidic alpha-synuclein fibril - polymorph L1A | Descriptor: | Alpha-synuclein | Authors: | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | Deposit date: | 2022-07-11 | Release date: | 2022-10-12 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | The 3D structure of lipidic fibrils of alpha-synuclein. Nat Commun, 13, 2022
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7JH7
| cardiac actomyosin complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | Authors: | Galkin, V.E, Schroeder, G.F. | Deposit date: | 2020-07-20 | Release date: | 2020-10-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex. Structure, 29, 2021
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8OQI
| Cryo-EM structure of the wild-type alpha-synuclein fibril. | Descriptor: | Alpha-synuclein | Authors: | Pesch, V, Reithofer, S, Ma, L, Flores-Fernandez, J.M, Oezduezenciler, P, Busch, Y, Lien, Y, Rudtke, O, Frieg, B, Schroeder, G.F, Wille, H, Tamgueney, G. | Deposit date: | 2023-04-12 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson's disease. Brain, 2024
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8OL6
| Murine type II Abeta fibril from tgAPPSwe mouse | Descriptor: | Amyloid-beta protein 42 | Authors: | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | Deposit date: | 2023-03-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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8OL5
| Murine type II Abeta fibril from ARTE10 mouse | Descriptor: | Amyloid-beta protein 42 | Authors: | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | Deposit date: | 2023-03-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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8OL2
| Murine type II Abeta fibril from APP23 mouse | Descriptor: | Amyloid-beta protein 42 | Authors: | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | Deposit date: | 2023-03-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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8OLO
| Murine type III Abeta fibril from ARTE10 mouse | Descriptor: | Amyloid-beta protein 42 | Authors: | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | Deposit date: | 2023-03-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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