5H7R
| |
5H7S
| |
8FY2
| E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2) | Descriptor: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | Authors: | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
|
|
8FY1
| E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2) | Descriptor: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | Authors: | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
|
|
5DIN
| |
8FY0
| E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) | Descriptor: | Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... | Authors: | Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
|
|
8GF5
| McrD binds asymmetrically to methyl-coenzyme M reductase improving active site accessibility during assembly | Descriptor: | 1-THIOETHANESULFONIC ACID, Coenzyme B, FACTOR 430, ... | Authors: | Joiner, A.M.N, Chadwick, G.L, Nayak, D.D. | Deposit date: | 2023-03-07 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | McrD binds asymmetrically to methyl-coenzyme M reductase improving active-site accessibility during assembly. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8GF6
| Apo-apo MCR assembly intermediate | Descriptor: | Methyl coenzyme M reductase, subunit D, Methyl-coenzyme M reductase subunit alpha, ... | Authors: | Joiner, A.M.N, Chadwick, G.L, Nayak, D.D. | Deposit date: | 2023-03-07 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | McrD binds asymmetrically to methyl-coenzyme M reductase improving active-site accessibility during assembly. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
6JX6
| Tetrameric form of Smac | Descriptor: | Diablo homolog, mitochondrial | Authors: | Sivaraman, J, Singh, S, Ng, J, Nayak, D. | Deposit date: | 2019-04-22 | Release date: | 2019-12-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.805 Å) | Cite: | Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activitiesin vitro. J.Biol.Chem., 294, 2019
|
|
6JX5
| Hect domain of AREL1 | Descriptor: | Apoptosis-resistant E3 ubiquitin protein ligase 1 | Authors: | Sivaraman, J, Singh, S, Ng, J, Nayak, D. | Deposit date: | 2019-04-22 | Release date: | 2019-12-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activitiesin vitro. J.Biol.Chem., 294, 2019
|
|