4O66
| Crystal Structure of SMARCAL1 HARP substrate recognition domain | Descriptor: | SODIUM ION, SULFATE ION, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 | Authors: | Mason, A.C, Eichman, B.F. | Deposit date: | 2013-12-20 | Release date: | 2014-05-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A structure-specific nucleic acid-binding domain conserved among DNA repair proteins. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
6RZC
| |
6RYQ
| |
6RZ1
| |
1BP5
| HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM | Descriptor: | PROTEIN (SERUM TRANSFERRIN) | Authors: | Jeffrey, P.D, Bewley, M.C, Macgillivray, R.T.A, Mason, A.B, Woodworth, R.C, Baker, E.N. | Deposit date: | 1998-08-12 | Release date: | 1999-01-13 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin. Biochemistry, 37, 1998
|
|
1BTJ
| HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM, CRYSTAL FORM 2 | Descriptor: | PROTEIN (SERUM TRANSFERRIN) | Authors: | Jeffrey, P.D, Bewley, M.C, Macgillivray, R.T.A, Mason, A.B, Woodworth, R.C, Baker, E.N. | Deposit date: | 1998-09-01 | Release date: | 1999-01-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin. Biochemistry, 37, 1998
|
|
1B3E
| HUMAN SERUM TRANSFERRIN, N-TERMINAL LOBE, EXPRESSED IN PICHIA PASTORIS | Descriptor: | CARBONATE ION, FE (III) ION, PROTEIN (SERUM TRANSFERRIN) | Authors: | Bewley, M.C, Tam, B.M, Grewal, J, He, S, Shewry, S, Murphy, M.E.P, Mason, A.B, Woodworth, R.C, Baker, E.N, Macgillivray, R.T.A. | Deposit date: | 1998-12-09 | Release date: | 1999-03-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-ray crystallography and mass spectroscopy reveal that the N-lobe of human transferrin expressed in Pichia pastoris is folded correctly but is glycosylated on serine-32. Biochemistry, 38, 1999
|
|
1A8F
| HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE | Descriptor: | CARBONATE ION, FE (III) ION, SERUM TRANSFERRIN | Authors: | Macgillivray, R.T.A, Moore, S.A, Chen, J, Anderson, B.F, Baker, H, Luo, Y, Bewley, M, Smith, C.A, Murphy, M.E.P, Wang, Y, Mason, A.B, Woodworth, R.C, Brayer, G.D, Baker, E.N. | Deposit date: | 1998-03-25 | Release date: | 1998-06-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release. Biochemistry, 37, 1998
|
|
1A8E
| HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE | Descriptor: | CARBONATE ION, FE (III) ION, SERUM TRANSFERRIN | Authors: | Macgillivray, R.T.A, Moore, S.A, Chen, J, Anderson, B.F, Baker, H, Luo, Y, Bewley, M, Smith, C.A, Murphy, M.E.P, Wang, Y, Mason, A.B, Woodworth, R.C, Brayer, G.D, Baker, E.N. | Deposit date: | 1998-03-24 | Release date: | 1998-06-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release. Biochemistry, 37, 1998
|
|
3FGS
| |
2VH0
| Structure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs | Descriptor: | 2-(5-chlorothiophen-2-yl)-N-[(3S)-1-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-2-oxopyrrolidin-3-yl]ethanesulfonamide, ACTIVATED FACTOR XA HEAVY CHAIN, ACTIVATED FACTOR XA LIGHT CHAIN, ... | Authors: | Young, R.J, Borthwick, A.D, Brown, D, Burns-Kurtis, C.L, Campbell, M, Chan, C, Charbaut, M, Convery, M.A, Diallo, H, Hortense, E, Irving, W.R, Kelly, H.A, King, N.P, Kleanthous, S, Mason, A.M, Pateman, A.J, Patikis, A, Pinto, I.L, Pollard, D.R, Senger, S, Shah, G.P, Toomey, J.R, Watson, N.S, Weston, H.E, Zhou, P. | Deposit date: | 2007-11-16 | Release date: | 2008-11-25 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs. Bioorg. Med. Chem. Lett., 18, 2008
|
|
2VH6
| Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs | Descriptor: | 2-(5-chlorothiophen-2-yl)-N-{(3S)-1-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-2-oxopyrrolidin-3-yl}ethanesulfonamide, ACTIVATED FACTOR XA HEAVY CHAIN, ACTIVATED FACTOR XA LIGHT CHAIN | Authors: | Young, R.J, Borthwick, A.D, Brown, D, Burns-Kurtis, C.L, Campbell, M, Chan, C, Charbaut, M, Chung, C.W, Convery, M.A, Kelly, H.A, King, N.P, Kleanthous, S, Mason, A.M, Pateman, A.J, Patikis, A.N, Pinto, I.L, Pollard, D.R, Senger, S, Shah, G.P, Toomey, J.R, Watson, N.S, Weston, H.E. | Deposit date: | 2007-11-19 | Release date: | 2008-12-16 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure and Property Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Biaryl P4 Motifs. Bioorg.Med.Chem.Lett., 18, 2008
|
|
1JQF
| Human Transferrin N-Lobe Mutant H249Q | Descriptor: | CARBONATE ION, FE (III) ION, POTASSIUM ION, ... | Authors: | Baker, H.M, Mason, A.B, He, Q.-Y, MacGillivray, R.T.A, Baker, E.N. | Deposit date: | 2001-08-06 | Release date: | 2001-10-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Ligand variation in the transferrin family: the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins. Biochemistry, 40, 2001
|
|
3MC2
| |
1D3K
| HUMAN SERUM TRANSFERRIN | Descriptor: | CARBONATE ION, FE (III) ION, SERUM TRANSFERRIN | Authors: | Yang, H.-W, MacGillivray, R.T.A, Chen, J, Luo, Y, Wang, Y, Brayer, G.D, Mason, A, Woodworth, R.C, Murphy, M.E.P. | Deposit date: | 1999-09-29 | Release date: | 2000-03-01 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron. Protein Sci., 9, 2000
|
|
1D4N
| HUMAN SERUM TRANSFERRIN | Descriptor: | CARBONATE ION, FE (III) ION, TRANSFERRIN | Authors: | Yang, H.-W, MacGillivray, R.T.A, Chen, J, Luo, Y, Wang, Y, Brayer, G.D, Mason, A, Woodworth, R.C, Murphy, M.E.P. | Deposit date: | 1999-10-04 | Release date: | 2000-03-01 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron. Protein Sci., 9, 2000
|
|
2CJI
| Crystal structure of a Human Factor Xa inhibitor complex | Descriptor: | 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... | Authors: | Watson, N.S, Campbell, M, Chan, C, Convery, M.A, Hamblin, J.N, Kelly, H.A, King, N.P, Mason, A.M, Mitchell, C, Patel, V.K, Senger, S, Shah, G.P, Weston, H.E, Whitworth, C, Young, R.J. | Deposit date: | 2006-04-03 | Release date: | 2006-05-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Design and Synthesis of Orally Active Pyrrolidin-2-One-Based Factor Xa Inhibitors Bioorg.Med.Chem.Lett., 16, 2006
|
|
1N7X
| HUMAN SERUM TRANSFERRIN, N-LOBE Y45E MUTANT | Descriptor: | CARBONATE ION, FE (III) ION, Serotransferrin | Authors: | Adams, T.E, Mason, A.B, He, Q.Y, Halbrooks, P.J, Briggs, S.K, Smith, V.C, Macgillivray, R.T, Everse, S.J. | Deposit date: | 2002-11-18 | Release date: | 2003-03-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | THE POSITION OF ARGININE 124 CONTROLS THE RATE OF IRON RELEASE FROM THE N-LOBE OF HUMAN SERUM TRANSFERRIN. A STRUCTURAL STUDY J.Biol.Chem., 278, 2003
|
|
1N7W
| Crystal Structure of Human Serum Transferrin, N-Lobe L66W mutant | Descriptor: | CARBONATE ION, FE (III) ION, Serotransferrin | Authors: | Adams, T.E, Mason, A.B, He, Q.Y, Halbrooks, P.J, Briggs, S.K, Smith, V.C, MacGillivray, R.T, Everse, S.J. | Deposit date: | 2002-11-18 | Release date: | 2003-03-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Position of Arginine 124 Controls the Rate of Iron Release from the N-lobe of Human Serum Transferrin. A Structural Study J.Biol.Chem., 278, 2003
|
|
1N84
| HUMAN SERUM TRANSFERRIN, N-LOBE | Descriptor: | CARBONATE ION, FE (III) ION, Serotransferrin | Authors: | Adams, T.E, Mason, A.B, He, Q.Y, Halbrooks, P.J, Briggs, S.K, Smith, V.C, Macgillivray, R.T, Everse, S.J. | Deposit date: | 2002-11-19 | Release date: | 2003-03-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | THE POSITION OF ARGININE 124 CONTROLS THE RATE OF IRON RELEASE FROM THE N-LOBE OF HUMAN SERUM TRANSFERRIN. A STRUCTURAL STUDY J.Biol.Chem., 278, 2003
|
|
2J4I
| CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX | Descriptor: | 1-PYRROLIDINEACETAMIDE, 3-[[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]AMINO]-ALPHA-METHYL-N-(1-METHYLETHYL)-N-[2-[(METHYLSULFONYL)AMINO]ETHYL]-2-OXO-, (ALPHAS,3S)-, ... | Authors: | Young, R.J, Campbell, M, Borthwick, A.D, Brown, D, Chan, C, Convery, M.A, Crowe, M.C, Dayal, S, Diallo, H, Kelly, H.A, Paul King, N, Kleanthous, S, Kurtis, C.L, Mason, A.M, Mordaunt, J.E, Patel, C, Pateman, A.J, Senger, S, Shah, G.P, Smith, P.W, Watson, N.S, Weston, H.E, Zhou, P. | Deposit date: | 2006-08-31 | Release date: | 2006-09-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure- and Property-Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Acyclic Alanyl Amides as P4 Motifs. Bioorg.Med.Chem.Lett., 16, 2006
|
|
1DTG
| HUMAN TRANSFERRIN N-LOBE MUTANT H249E | Descriptor: | CARBONATE ION, FE (III) ION, TRANSFERRIN | Authors: | MacGillivray, R.T, Bewley, M.C, Smith, C.A, He, Q.Y, Mason, A.B. | Deposit date: | 2000-01-12 | Release date: | 2000-01-21 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release. Biochemistry, 39, 2000
|
|
1OQG
| Crystal structure of the D63E mutant of the N-lobe human transferrin | Descriptor: | CARBONATE ION, FE (III) ION, Serotransferrin | Authors: | Baker, H.M, He, Q.-Y, Brigg, S.K, Mason, A.B, Baker, E.N. | Deposit date: | 2003-03-09 | Release date: | 2003-03-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin Biochemistry, 42, 2003
|
|
1OQH
| Crystal Structure of the R124A mutant of the N-lobe human transferrin | Descriptor: | CARBONATE ION, FE (III) ION, POTASSIUM ION, ... | Authors: | Baker, H.M, He, Q.-Y, Brigg, S.K, Mason, A.B, N Baker, E. | Deposit date: | 2003-03-10 | Release date: | 2003-03-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin Biochemistry, 42, 2003
|
|
2O7U
| Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin | Descriptor: | CARBONATE ION, FE (III) ION, Serotransferrin | Authors: | Baker, H.M, Nurizzo, D, Mason, A.B, Baker, E.N. | Deposit date: | 2006-12-11 | Release date: | 2007-01-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of two mutants that probe the role in iron release of the dilysine pair in the N-lobe of human transferrin. Acta Crystallogr.,Sect.D, 63, 2007
|
|