6YS8
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6SD5
| Structure of the RBM2 inner ring of Salmonella flagella MS-ring protein FliF with 22-fold symmetry applied | Descriptor: | Flagellar M-ring protein | Authors: | Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. | Deposit date: | 2019-07-26 | Release date: | 2020-03-18 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation. Nat Microbiol, 5, 2020
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6SD4
| Structure of the RBM3/collar region of the Salmonella flagella MS-ring protein FliF with 34-fold symmetry applied | Descriptor: | Flagellar M-ring protein | Authors: | Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. | Deposit date: | 2019-07-26 | Release date: | 2020-03-18 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation. Nat Microbiol, 5, 2020
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2XRC
| Human complement factor I | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, HUMAN COMPLEMENT FACTOR I | Authors: | Roversi, P, Johnson, S, Lea, S.M. | Deposit date: | 2010-09-13 | Release date: | 2011-07-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structural Basis for Complement Factor I Control and its Disease-Associated Sequence Polymorphisms. Proc.Natl.Acad.Sci.USA, 108, 2011
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2XRD
| Structure of the N-terminal four domains of the complement regulator Rat Crry | Descriptor: | COMPLEMENT REGULATORY PROTEIN CRRY | Authors: | Leath, K.J, Roversi, P, Johnson, S, Morgan, B.P, Lea, S.M. | Deposit date: | 2010-09-14 | Release date: | 2011-06-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structures of the Rat Complement Regulator Crry. Acta Crystallogr.,Sect.F, 67, 2011
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2XGA
| MTSL spin-labelled Shigella Flexneri Spa15 | Descriptor: | S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, SURFACE PRESENTATION OF ANTIGENS PROTEIN SPAK | Authors: | Lillington, J.E.D, Johnson, S, Lea, S.M. | Deposit date: | 2010-06-02 | Release date: | 2010-12-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Shigella Flexneri Spa15 Crystal Structure Verified in Solution by Double Electron Electron Resonance. J.Mol.Biol., 405, 2011
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2XRB
| Structure of the N-terminal four domains of the complement regulator Rat Crry | Descriptor: | 1,2-ETHANEDIOL, COMPLEMENT REGULATORY PROTEIN CRRY, SULFATE ION | Authors: | Leath, K.J, Roversi, P, Johnson, S, Morgan, B.P, Lea, S.M. | Deposit date: | 2010-09-13 | Release date: | 2011-06-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of the Rat Complement Regulator Crry. Acta Crystallogr.,Sect.F, 67, 2011
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6TRE
| Structure of the RBM3/collar region of the Salmonella flagella MS-ring protein FliF with 32-fold symmetry applied | Descriptor: | Flagellar M-ring protein | Authors: | Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. | Deposit date: | 2019-12-18 | Release date: | 2020-03-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the bacterial flagellar rotor MS-ring: a minimum inventory/maximum diversity system. To Be Published
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2XXS
| Solution structure of the N-terminal domain of the Shigella type III secretion protein MxiG | Descriptor: | PROTEIN MXIG | Authors: | McDowell, M.A, Johnson, S, Deane, J.E, McDonnell, J.M, Lea, S.M. | Deposit date: | 2010-11-11 | Release date: | 2011-07-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and Functional Studies on the N-Terminal Domain of the Shigella Type III Secretion Protein Mxig. J.Biol.Chem., 286, 2011
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2YEQ
| Structure of PhoD | Descriptor: | 1,2-ETHANEDIOL, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ALKALINE PHOSPHATASE D, ... | Authors: | Lillington, J.E.D, Rodriguez, F, Roversi, P, Johnson, S.J, Berks, B, Lea, S.M. | Deposit date: | 2011-03-30 | Release date: | 2012-04-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal Structure of the Bacillus Subtilis Phosphodiesterase Phod Reveals an Iron and Calcium-Containing Active Site. J.Biol.Chem., 289, 2014
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2YEZ
| COMPLEX OF A B21 CHICKEN MHC CLASS I MOLECULE AND A 10MER CHICKEN PEPTIDE | Descriptor: | 14-3-3 PROTEIN THETA, BETA-2-MICROGLOBULIN, MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I GLYCOPROTEIN HAPLOTYPE B21 | Authors: | Chappell, P, Roversi, P, Harrison, M.C, Mears, L.E, Kaufman, J.F, Lea, S.M. | Deposit date: | 2011-03-31 | Release date: | 2012-04-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding. Elife, 4, 2015
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2YF2
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2YBY
| Structure of domains 6 and 7 of the mouse complement regulator Factor H | Descriptor: | 1,2-ETHANEDIOL, COMPLEMENT FACTOR H | Authors: | Everett, R.J, Caesar, J.J.E, Johnson, S.J, Tang, C.M, Lea, S.M. | Deposit date: | 2011-03-30 | Release date: | 2012-04-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules. Plos Pathog., 8, 2012
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6F2D
| A FliPQR complex forms the core of the Salmonella type III secretion system export apparatus. | Descriptor: | Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliQ, Flagellar biosynthetic protein FliR | Authors: | Johnson, S, Kuhlen, L, Abrusci, P, Lea, S.M. | Deposit date: | 2017-11-24 | Release date: | 2018-07-04 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure of the core of the type III secretion system export apparatus. Nat. Struct. Mol. Biol., 25, 2018
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4V1J
| Structure of Neisseria meningitidis Major Pillin | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FIMBRIAL PROTEIN | Authors: | Harding, R.J, Exley, R, Tang, C.M, Caesar, J.J.E, Lea, S.M. | Deposit date: | 2014-09-29 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Tstructure of Neisseria Meningitidis Major Pillin To be Published
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4UWQ
| Crystal structure of the disulfide-linked complex of the thiosulfodyrolase SoxB with the carrier-protein SoxYZ from Thermus thermophilus | Descriptor: | MANGANESE (II) ION, SOXY PROTEIN, SOXZ, ... | Authors: | Grabarczyk, D.B, Chappell, P.E, Johnson, S, Stelzl, L.S, Lea, S.M, Berks, B.C. | Deposit date: | 2014-08-14 | Release date: | 2015-12-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.28 Å) | Cite: | Structural Basis for Specificity and Promiscuity in a Carrier Protein/Enzyme System from the Sulfur Cycle Proc.Natl.Acad.Sci.USA, 112, 2015
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4V2K
| Crystal structure of the thiosulfate dehydrogenase TsdA in complex with thiosulfate | Descriptor: | HEME C, THIOSULFATE, THIOSULFATE DEHYDROGENASE | Authors: | Grabarczyk, D.B, Chappell, P.E, Eisel, B, Johnson, S, Lea, S.M, Berks, B.C. | Deposit date: | 2014-10-10 | Release date: | 2015-02-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Mechanism of Thiosulfate Oxidation in the Soxa Family of Cysteine-Ligated Cytochromes J.Biol.Chem., 290, 2015
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7NVG
| Salmonella flagellar basal body refined in C1 map | Descriptor: | Basal-body rod modification protein FlgD, Flagellar L-ring protein, Flagellar M-ring protein, ... | Authors: | Johnson, S, Furlong, E, Lea, S.M. | Deposit date: | 2021-03-15 | Release date: | 2021-05-05 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular structure of the intact bacterial flagellar basal body. Nat Microbiol, 6, 2021
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7NVH
| Cryo-EM structure of the mycolic acid transporter MmpL3 from M. tuberculosis | Descriptor: | 2-decyl-2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}dodecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Trehalose monomycolate exporter MmpL3 | Authors: | Adams, O, Deme, J.C, Parker, J.L, Lea, S.M, Newstead, S. | Deposit date: | 2021-03-15 | Release date: | 2021-06-16 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target. Structure, 29, 2021
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7NQK
| Cryo-EM structure of the mammalian peptide transporter PepT2 | Descriptor: | Solute carrier family 15 member 2, nanobody | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | Deposit date: | 2021-03-01 | Release date: | 2021-07-07 | Last modified: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals. Sci Adv, 7, 2021
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2V6L
| Molecular Model of a Type III Secretion System Needle | Descriptor: | MXIH | Authors: | Deane, J.E, Roversi, P, Cordes, F.S, Johnson, S, Kenjale, R, Daniell, S, Booy, F, Picking, W.L, Picking, W.D, Blocker, A.J, Lea, S.M. | Deposit date: | 2007-07-19 | Release date: | 2007-07-31 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (16 Å) | Cite: | Molecular model of a type III secretion system needle: Implications for host-cell sensing. Proc. Natl. Acad. Sci. U.S.A., 103, 2006
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4TT9
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2J8B
| High resolution structure of human CD59 | Descriptor: | CD59 GLYCOPROTEIN | Authors: | Leath, K.J, Johnson, S, Roversi, P, Morgan, B.P, Smith, R.A.G, Lea, S.M. | Deposit date: | 2006-10-24 | Release date: | 2007-08-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | High-Resolution Structures of Bacterially Expressed Soluble Human Cd59. Acta Crystallogr.,Sect.F, 63, 2007
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2JAA
| SeMet substituted Shigella Flexneri Ipad | Descriptor: | INVASIN IPAD | Authors: | Johnson, S, Roversi, P, Espina, M, Olive, A, Deane, J.E, Birket, S, Field, T, Picking, W.D, Blocker, A.J, Galyov, E.E, Picking, W.L, Lea, S.M. | Deposit date: | 2006-11-24 | Release date: | 2006-11-30 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Self-Chaperoning of the Type III Secretion System Needle Tip Proteins Ipad and Bipd. J.Biol.Chem., 282, 2007
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5LHX
| PB3 Domain of Drosophila melanogaster PLK4 (Sak) | Descriptor: | Serine/threonine-protein kinase PLK4 | Authors: | Cottee, M.A, Lea, S.M. | Deposit date: | 2016-07-13 | Release date: | 2017-03-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies. Biol Open, 6, 2017
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