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PDB: 16 results

4TKO
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BU of 4tko by Molmil
Structure of the periplasmic adaptor protein EmrA
Descriptor: EmrA, ISOPROPYL ALCOHOL, MAGNESIUM ION
Authors:Hinchliffe, P, Greene, N.P, Paterson, N.G, Crow, A, Hughes, C, Koronakis, V.
Deposit date:2014-05-27
Release date:2014-07-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump.
Febs Lett., 588, 2014
2V4D
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BU of 2v4d by Molmil
Re-refinement of MexA adaptor protein
Descriptor: MULTIDRUG RESISTANCE PROTEIN MEXA, SULFATE ION
Authors:Symmons, M.F, Bokma, E, Koronakis, E, Hughes, C, Koronakis, V.
Deposit date:2008-09-18
Release date:2009-04-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Assembled Structure of a Complete Tripartite Bacterial Multidrug Efflux Pump.
Proc.Natl.Acad.Sci.USA, 106, 2009
1EK9
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BU of 1ek9 by Molmil
2.1A X-RAY STRUCTURE OF TOLC: AN INTEGRAL OUTER MEMBRANE PROTEIN AND EFFLUX PUMP COMPONENT FROM ESCHERICHIA COLI
Descriptor: OUTER MEMBRANE PROTEIN TOLC
Authors:Koronakis, V, Sharff, A.J, Koronakis, E, Luisi, B, Hughes, C.
Deposit date:2000-03-07
Release date:2000-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export.
Nature, 405, 2000
2WMZ
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Structure of a mutated TolC
Descriptor: CHLORIDE ION, OUTER MEMBRANE PROTEIN TOLC, SODIUM ION, ...
Authors:Hinchliffe, P, Pei, X.Y, Symmons, M.F, Koronakis, E, Hughes, C, Koronakis, V.
Deposit date:2009-07-03
Release date:2011-01-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of Sequential Open States in a Symmetrical Opening Transition of the Tolc Exit Duct.
Proc.Natl.Acad.Sci.USA, 108, 2011
6F5H
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BU of 6f5h by Molmil
Crystal structure of USP7 in complex with a 4-hydroxypiperidine based inhibitor
Descriptor: 3-[[4-oxidanyl-1-[(3~{R})-3-phenylbutanoyl]piperidin-4-yl]methyl]-6-(2-pyrrolidin-1-ylethylamino)pyrimidin-4-one, GLYCEROL, SULFATE ION, ...
Authors:Harrison, T, Gavory, G, O'Dowd, C, Helm, M, Flasz, J, Dossang, A, Hughes, C, Cassidy, E, McClelland, K, Odrzywol, E, Page, N, Barker, O, Miel, H, Feutron-Burton, S, Rountree, J.S.S.
Deposit date:2017-12-01
Release date:2018-04-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors.
ACS Med Chem Lett, 9, 2018
1MY5
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BU of 1my5 by Molmil
NF-kappaB p65 subunit dimerization domain homodimer
Descriptor: NF-kappaB p65 (RelA) subunit
Authors:Huxford, T, Mishler, D, Phelps, C.B, Huang, D.-B, Sengchanthalangsy, L.L, Reeves, R, Hughes, C.A, Komives, E.A, Ghosh, G.
Deposit date:2002-10-03
Release date:2002-12-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/I kappaB alpha complex formation
J.Mol.Biol., 324, 2002
5N9R
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BU of 5n9r by Molmil
Crystal structure of USP7 in complex with a potent, selective and reversible small-molecule inhibitor
Descriptor: 7-bromanyl-3-[[4-oxidanyl-1-[(3~{R})-3-phenylbutanoyl]piperidin-4-yl]methyl]thieno[3,2-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Harrison, T, Gavory, G, O'Dowd, C, Helm, M, Flasz, I, Arkoudis, E, Dossang, A, Hughes, C, Cassidy, E, McClelland, K, Odrzywol, E, Page, N, Barker, O, Miel, H.
Deposit date:2017-02-27
Release date:2017-12-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.
Nat. Chem. Biol., 14, 2018
5N9T
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Crystal structure of USP7 in complex with a potent, selective and reversible small-molecule inhibitor
Descriptor: 3-[4-(aminomethyl)phenyl]-2-methyl-6-[[4-oxidanyl-1-[(3~{R})-4,4,4-tris(fluoranyl)-3-phenyl-butanoyl]piperidin-4-yl]methyl]pyrazolo[4,3-d]pyrimidin-7-one, GLYCEROL, SULFATE ION, ...
Authors:Harrison, T, Gavory, G, O'Dowd, C, Helm, M, Flasz, J, Arkoudis, E, Dossang, A, Hughes, C, Cassidy, E, McClelland, K, Odrzywol, E, Page, N, Barker, O, Miel, H.
Deposit date:2017-02-27
Release date:2017-12-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.
Nat. Chem. Biol., 14, 2018
1MY7
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BU of 1my7 by Molmil
NF-kappaB p65 subunit dimerization domain homodimer N202R mutation
Descriptor: NF-kappaB p65 (RelA) subunit
Authors:Huxford, T, Mishler, D, Phelps, C.B, Huang, D.-B, Sengchanthalangsy, L.L, Reeves, R, Hughes, C.A, Komives, E.A, Ghosh, G.
Deposit date:2002-10-03
Release date:2002-12-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaB alpha complex formation
J.Mol.Biol., 324, 2002
1T5E
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BU of 1t5e by Molmil
The structure of MexA
Descriptor: D-Glyceraldehyde, GLYCEROL, Multidrug resistance protein mexA
Authors:Higgins, M.K, Bokma, E, Koronakis, E, Hughes, C, Koronakis, V.
Deposit date:2004-05-04
Release date:2004-05-18
Last modified:2020-07-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the periplasmic component of a bacterial drug efflux pump
Proc.Natl.Acad.Sci.USA, 101, 2004
4WHN
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BU of 4whn by Molmil
Structure of toxin-activating acyltransferase (TAAT)
Descriptor: ApxC, CITRIC ACID
Authors:Crow, A, Greene, N.P, Hughes, C, Koronakis, V.
Deposit date:2014-09-23
Release date:2015-06-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of a bacterial toxin-activating acyltransferase.
Proc.Natl.Acad.Sci.USA, 112, 2015
2XMN
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BU of 2xmn by Molmil
High resolution snapshots of defined TolC open states present an iris- like movement of periplasmic entrance helices
Descriptor: CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Outer membrane protein TolC
Authors:Pei, X.Y, Koronakis, E, Hughes, C, Koronakis, V.
Deposit date:2010-07-28
Release date:2011-01-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of sequential open states in a symmetrical opening transition of the TolC exit duct.
Proc. Natl. Acad. Sci. U.S.A., 108, 2011
1TQQ
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BU of 1tqq by Molmil
Structure of TolC in complex with hexamminecobalt
Descriptor: COBALT HEXAMMINE(III), Outer membrane protein tolC
Authors:Higgins, M.K, Eswaran, J, Edwards, P.C, Schertler, G.F, Hughes, C, Koronakis, V.
Deposit date:2004-06-18
Release date:2004-07-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug effllux protein TolC
J.Mol.Biol., 342, 2004
4KKS
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BU of 4kks by Molmil
Crystal Structure of BesA (C2 form)
Descriptor: Membrane fusion protein, PHOSPHATE ION
Authors:Greene, N.P, Hinchliffe, P, Crow, A, Ababou, A, Hughes, C, Koronakis, V.
Deposit date:2013-05-06
Release date:2013-07-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirochete Borrelia burgdorferi.
Febs Lett., 587, 2013
4KKT
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BU of 4kkt by Molmil
Crystal Structure of BesA (P21 form)
Descriptor: Membrane fusion protein
Authors:Greene, N.P, Hinchliffe, P, Crow, A, Ababou, A, Hughes, C, Koronakis, V.
Deposit date:2013-05-06
Release date:2013-07-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirochete Borrelia burgdorferi.
Febs Lett., 587, 2013
4KKU
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BU of 4kku by Molmil
Structure of BesA (Selenomethinone derivative - P212121)
Descriptor: Membrane fusion protein
Authors:Greene, N.P, Hinchliffe, P, Crow, A, Ababou, A, Hughes, C, Koronakis, V.
Deposit date:2013-05-06
Release date:2013-07-10
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirochete Borrelia burgdorferi.
Febs Lett., 587, 2013

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