5N9T
Crystal structure of USP7 in complex with a potent, selective and reversible small-molecule inhibitor
Summary for 5N9T
Entry DOI | 10.2210/pdb5n9t/pdb |
Related | 5N9R |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 7, SULFATE ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | usp7, reversible, inhibitor, selective, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q93009 |
Total number of polymer chains | 2 |
Total formula weight | 84713.36 |
Authors | Harrison, T.,Gavory, G.,O'Dowd, C.,Helm, M.,Flasz, J.,Arkoudis, E.,Dossang, A.,Hughes, C.,Cassidy, E.,McClelland, K.,Odrzywol, E.,Page, N.,Barker, O.,Miel, H. (deposition date: 2017-02-27, release date: 2017-12-06, Last modification date: 2024-01-17) |
Primary citation | Gavory, G.,O'Dowd, C.R.,Helm, M.D.,Flasz, J.,Arkoudis, E.,Dossang, A.,Hughes, C.,Cassidy, E.,McClelland, K.,Odrzywol, E.,Page, N.,Barker, O.,Miel, H.,Harrison, T. Discovery and characterization of highly potent and selective allosteric USP7 inhibitors. Nat. Chem. Biol., 14:118-125, 2018 Cited by PubMed: 29200206DOI: 10.1038/nchembio.2528 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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