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PDB: 16 results

4AD6
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Synthesis and SAR of guanine based analogues for HPPK inhibitors
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 7-(2-HYDROXYETHYL)-8-MERCAPTOGUANINE
Authors:Chhabra, S, Peat, T.S, Swarbrick, J.
Deposit date:2011-12-22
Release date:2013-01-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Exploring the Chemical Space Around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme Hppk.
Plos One, 8, 2013
2MD0
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Solution structure of ShK-like immunomodulatory peptide from Ancylostoma caninum (hookworm)
Descriptor: AcK1
Authors:Chhabra, S, Swarbrick, J.D, Mohanty, B, Chang, S.C, Chandy, G.K, Pennington, M.W, Norton, R.S.
Deposit date:2013-08-28
Release date:2014-07-02
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases.
Faseb J., 28, 2014
2MCR
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BU of 2mcr by Molmil
Solution structure of ShK-like immunomodulatory peptide from Brugia malayi (filarial worm)
Descriptor: Probable zinc metalloproteinase, putative
Authors:Chhabra, S, Swarbrick, J.D, Pennington, M.W, Chang, S.C, Norton, R.S.
Deposit date:2013-08-22
Release date:2014-07-02
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases.
Faseb J., 28, 2014
2MTT
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Non-reducible analogues of alpha-conotoxin RgIA: [3,12]-cis dicarba RgIA
Descriptor: Dicarba Analogues of alpha-Conotoxin RgIA
Authors:Chhabra, S, Robinson, S.D, Norton, R.S.
Deposit date:2014-08-31
Release date:2014-11-26
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets.
J.Med.Chem., 57, 2014
2MTO
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BU of 2mto by Molmil
Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA
Descriptor: Alpha-conotoxin RgIA
Authors:Chhabra, S, Robinson, S, Norton, R.
Deposit date:2014-08-26
Release date:2014-11-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets.
J.Med.Chem., 57, 2014
2MTU
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Non-reducible analogues of alpha-conotoxin RgIA: [3,12]-trans dicarba RgIA
Descriptor: Dicarba Analogues of alpha-Conotoxin RgIA
Authors:Chhabra, S, Robinson, S.D, Norton, R.S.
Deposit date:2014-09-01
Release date:2014-11-26
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets.
J.Med.Chem., 57, 2014
5U0W
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BU of 5u0w by Molmil
E. coli dihydropteroate synthase complexed with 9-methylguanine
Descriptor: 9-METHYLGUANINE, ACETIC ACID, Dihydropteroate synthase
Authors:Chhabra, S, Dennis, M.L, Peat, T.S, Swarbrick, J.D.
Deposit date:2016-11-27
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.968 Å)
Cite:8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.
Chemistry, 24, 2018
5L34
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BU of 5l34 by Molmil
Calculated solution structure of [D-Trp3]-Contryphan-Vc2
Descriptor: [D-Trp3]-Contryphan-Vc2
Authors:Drane, S.B, Chhabra, S, MacRaild, C.A.
Deposit date:2016-08-03
Release date:2017-03-08
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue.
Toxicon, 129, 2017
7KNN
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Solution structure of the alpha-conotoxin analogue [2-8]-alkyne Vc1.1
Descriptor: Alpha-conotoxin Vc1a
Authors:MacRaild, C.A, Robinson, S.D, Chhabra, S, Norton, R.S.
Deposit date:2020-11-05
Release date:2021-09-15
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Alkyne-Bridged alpha-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models.
J.Med.Chem., 64, 2021
3QBC
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BU of 3qbc by Molmil
Structure and design of a new pterin site inhibitor of S. aureus HPPK
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-8-sulfanyl-1,9-dihydro-6H-purin-6-one
Authors:Peat, T.S, Chhabra, S, Swarbrick, J.D.
Deposit date:2011-01-12
Release date:2012-01-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor
Plos One, 7, 2012
3PSN
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Crystal structure of mouse VPS29 complexed with Mn2+
Descriptor: MANGANESE (II) ION, Vacuolar protein sorting-associated protein 29
Authors:Swarbrick, J, Shaw, D, Chhabra, S, Ghai, R, Valkov, E, Norwood, S, Collins, B.
Deposit date:2010-12-02
Release date:2010-12-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational dynamics and biomolecular interactions of VPS29 studied by NMR and X-ray crystallography
To be Published
3PSO
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BU of 3pso by Molmil
Crystal structure of mouse VPS29 complexed with Zn2+
Descriptor: Vacuolar protein sorting-associated protein 29, ZINC ION
Authors:Swarbrick, J, Shaw, D, Chhabra, S, Ghai, R, Valkov, E, Norwood, S, Collins, B.
Deposit date:2010-12-02
Release date:2010-12-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Conformational dynamics and biomolecular interactions of VPS29 studied by NMR and X-ray crystallography
To be Published
3MMW
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BU of 3mmw by Molmil
Crystal structure of endoglucanase Cel5A from the hyperthermophilic Thermotoga maritima
Descriptor: CADMIUM ION, Endoglucanase
Authors:Pereira, J.H, Chen, Z, McAndrew, R.P, Sapra, R, Chhabra, S.R, Sale, K.L.
Deposit date:2010-04-20
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Biochemical characterization and crystal structure of endoglucanase Cel5A from the hyperthermophilic Thermotoga maritima.
J.Struct.Biol., 172, 2010
3MMU
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BU of 3mmu by Molmil
Crystal structure of endoglucanase Cel5A from the hyperthermophilic Thermotoga maritima
Descriptor: CADMIUM ION, Endoglucanase, NICKEL (II) ION
Authors:Pereira, J.H, Chen, Z, McAndrew, R.P, Sapra, R, Chhabra, S.R, Sale, K.L, Simmons, B.A, Adams, P.D.
Deposit date:2010-04-20
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Biochemical characterization and crystal structure of endoglucanase Cel5A from the hyperthermophilic Thermotoga maritima.
J.Struct.Biol., 172, 2010
2N24
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BU of 2n24 by Molmil
Solution NMR structure of Contryphan-Vc1
Descriptor: O2_contryphan_Vc1
Authors:Robinson, S.D, Chhabra, S, Norton, R.S.
Deposit date:2015-04-27
Release date:2016-02-03
Last modified:2019-12-25
Method:SOLUTION NMR
Cite:A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed beta-Hairpin Fold.
Structure, 24, 2016
2N8H
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BU of 2n8h by Molmil
Structural basis for the inhibition of voltage-gated sodium channels with conotoxin-muOxi-GVIIJ
Descriptor: conotoxin-muOxi-GVIIJ
Authors:Green, B.R, Chhabra, S, Norton, R.S.
Deposit date:2015-10-15
Release date:2016-02-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin mu O-GVIIJ.
J.Biol.Chem., 291, 2016

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