6L6G
 
 | | Crystal structure of SeMet_Lpg0189 | | Descriptor: | GLYCEROL, Uncharacterized protein Lpg0189 | | Authors: | Ge, H, Chen, X. | | Deposit date: | 2019-10-29 | | Release date: | 2019-11-27 | | Last modified: | 2020-01-15 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Crystal structure of a hypothetical T2SS effector Lpg0189 from Legionella pneumophila reveals a novel protein fold.
Biochem.Biophys.Res.Commun., 521, 2020
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5ZQZ
 | | Structure of human mitochondrial trifunctional protein, tetramer | | Descriptor: | Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta | | Authors: | Liang, K, Li, N, Dai, J, Wang, X, Liu, P, Chen, X, Wang, C, Gao, N, Xiao, J. | | Deposit date: | 2018-04-20 | | Release date: | 2018-06-20 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-EM structure of human mitochondrial trifunctional protein
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5ZRV
 | | Structure of human mitochondrial trifunctional protein, octamer | | Descriptor: | Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta | | Authors: | Liang, K, Li, N, Dai, J, Wang, X, Liu, P, Chen, X, Wang, C, Gao, N, Xiao, J. | | Deposit date: | 2018-04-25 | | Release date: | 2018-06-20 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (7.7 Å) | | Cite: | Cryo-EM structure of human mitochondrial trifunctional protein
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4RZM
 | | Crystal structure of the Lsd19-lasalocid A complex | | Descriptor: | CHLORIDE ION, Epoxide hydrolase LasB, FORMIC ACID, ... | | Authors: | Mathews, I.I, Hotta, K, Chen, X, Kim, C.-Y. | | Deposit date: | 2014-12-22 | | Release date: | 2015-01-21 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Epoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis.
J.Am.Chem.Soc., 137, 2015
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8GRG
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8GRU
 | | Crystal structure of a constitutively active mutant of the alpha beta heterodimer of human IDH3 in complex with ICT, NAD and Ca | | Descriptor: | CALCIUM ION, Human IDH3 alpha subunit, ISOCITRIC ACID, ... | | Authors: | Sun, P, Chen, X, Ding, J. | | Deposit date: | 2022-09-02 | | Release date: | 2022-11-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.847 Å) | | Cite: | Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction.
J.Biol.Chem., 298, 2022
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8GS5
 | | Crystal structure of a constitutively active mutant of human IDH3 holoenzyme in apo form | | Descriptor: | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, ... | | Authors: | Sun, P, Chen, X, Ding, J. | | Deposit date: | 2022-09-04 | | Release date: | 2022-11-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (4.486 Å) | | Cite: | Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction.
J.Biol.Chem., 298, 2022
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8GRB
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8GRH
 | | Crystal structure of a constitutively active mutant of the alpha gamma heterodimer of human IDH3 in complex with CIT | | Descriptor: | CITRIC ACID, Human IDH3 alpha subunit, Isocitrate dehydrogenase [NAD] subunit gamma, ... | | Authors: | Sun, P, Chen, X, Ding, J. | | Deposit date: | 2022-09-01 | | Release date: | 2022-11-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.506 Å) | | Cite: | Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction.
J.Biol.Chem., 298, 2022
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8HHG
 | | The bacterial divisome protein complex FtsB-FtsL-FtsQ | | Descriptor: | Cell division protein FtsB, Cell division protein FtsL, Cell division protein FtsQ | | Authors: | Nguyen, V.H.T, Chen, X. | | Deposit date: | 2022-11-16 | | Release date: | 2023-04-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome.
Nat Commun, 14, 2023
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8HHH
 | | The bacterial divisome protein complex FtsB-FtsL-FtsQ | | Descriptor: | Cell division protein FtsB, Cell division protein FtsL, Cell division protein FtsQ | | Authors: | Nguyen, V.H.T, Chen, X. | | Deposit date: | 2022-11-16 | | Release date: | 2023-04-26 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome.
Nat Commun, 14, 2023
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5X7D
 | | Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist | | Descriptor: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Liu, X, Ahn, S, Kahsai, A.W, Meng, K.-C, Latorraca, N.R, Pani, B, Venkatakrishnan, A.J, Masoudi, A, Weis, W.I, Dror, R.O, Chen, X, Lefkowitz, R.J, Kobilka, B.K. | | Deposit date: | 2017-02-25 | | Release date: | 2017-08-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.703 Å) | | Cite: | Mechanism of intracellular allosteric beta 2AR antagonist revealed by X-ray crystal structure.
Nature, 548, 2017
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6M4P
 | | Cytochrome P450 monooxygenase StvP2 substrate-bound structure | | Descriptor: | 6-methoxy-streptovaricin C, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Sun, G, Hu, C, Mei, Q, Luo, M, Chen, X, Li, Z, Liu, Y, Deng, Z, Zhang, Z, Sun, Y. | | Deposit date: | 2020-03-08 | | Release date: | 2020-08-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis.
Nat Commun, 11, 2020
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8JDB
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxyoctanoic acid | | Descriptor: | (2R)-2-oxidanyloctanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-13 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDD
 | | Crystal structure of H405A mLDHD in apo form | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, mitochondrial | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-13 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDT
 | | Crystal structure of mLDHD in complex with 2-ketobutanoic acid | | Descriptor: | 2-KETOBUTYRIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDQ
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxyisocaproic acid | | Descriptor: | (2R)-2-hydroxy-4-methylpentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDG
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxybutanoic acid | | Descriptor: | (2R)-2-oxidanylbutanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-14 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDU
 | | Crystal structure of mLDHD in complex with 2-ketovaleric acid | | Descriptor: | 2-oxopentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDN
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxyvaleric acid | | Descriptor: | (2R)-2-oxidanylpentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDC
 | | Crystal structure of mLDHD in apo form | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, mitochondrial | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-13 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.696 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDO
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxyhexanoic acid | | Descriptor: | (2R)-2-hydroxyhexanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDX
 | | Crystal structure of mLDHD in complex with 2-ketoisovaleric acid | | Descriptor: | 3-METHYL-2-OXOBUTANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDZ
 | | Crystal structure of mLDHD in complex with 2-keto-3-methylvaleric acid | | Descriptor: | (3S)-3-methyl-2-oxopentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDF
 | | Crystal structure of H405A mLDHD in complex with D-lactate | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, LACTIC ACID, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-13 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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