4F6X
| Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1112 | Descriptor: | 1-[3-(hexyloxy)benzyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid, D(-)-TARTARIC ACID, Dehydrosqualene synthase, ... | Authors: | Lin, F.-Y, Zhang, Y, Liu, Y.-L, Oldfield, E. | Deposit date: | 2012-05-15 | Release date: | 2012-06-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett, 3, 2012
|
|
4GA3
| Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260 | Descriptor: | 1-butyl-3-(2-hydroxy-2,2-diphosphonoethyl)-1H-imidazol-3-ium, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... | Authors: | Liu, Y.-L, Zhang, Y, Oldfield, E. | Deposit date: | 2012-07-24 | Release date: | 2013-05-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis. ACS MED.CHEM.LETT., 4, 2013
|
|
5J5C
| Crystal structure of ARL1-GTP and DCB domain of BIG1 complex | Descriptor: | ADP-ribosylation factor-like protein 1, Brefeldin A-inhibited guanine nucleotide-exchange protein 1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Wang, R, Wang, Z, Zhang, T, Ding, J. | Deposit date: | 2016-04-02 | Release date: | 2016-09-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1 J Mol Cell Biol, 2016
|
|
6NZT
| |
4H2M
| Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1408 | Descriptor: | 2,2'-{benzene-1,3-diylbis[ethyne-2,1-diyl(5-bromobenzene-3,1-diyl)]}diethanamine, Undecaprenyl pyrophosphate synthase | Authors: | Zhu, W, Oldfield, E. | Deposit date: | 2012-09-12 | Release date: | 2012-12-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Antibacterial drug leads targeting isoprenoid biosynthesis. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
4H3A
| |
4H2O
| |
4H2J
| |
4H8E
| |
4H38
| |
4H3C
| |
8ESM
| Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor | Descriptor: | Diacylglycerol O-acyltransferase 1, {(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic acid | Authors: | Sui, X, Kun, W, Walther, T, Farese, R, Liao, M. | Deposit date: | 2022-10-14 | Release date: | 2023-06-07 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14, 2023
|
|
8ETM
| Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor | Descriptor: | Diacylglycerol O-acyltransferase 1, [(1S,4r)-4-{4-[(4S)-2-({[4-(trifluoromethoxy)phenyl]methyl}carbamoyl)imidazo[1,2-a]pyridin-6-yl]phenyl}cyclohexyl]acetic acid | Authors: | Sui, X, Kun, W, Walther, T, Farese, R, Liao, M. | Deposit date: | 2022-10-17 | Release date: | 2023-06-07 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14, 2023
|
|
5AEL
| T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-597 | Descriptor: | FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, {2-[3-(hex-1-yn-1-yl)pyridinium-1-yl]ethane-1,1-diyl}bis(phosphonate) | Authors: | Yang, G, Oldfield, E, No, J.H. | Deposit date: | 2014-12-26 | Release date: | 2015-10-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation. Antimicrob.Agents Chemother., 59, 2015
|
|
5IQ7
| Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide. | Descriptor: | 10E8-S74W Heavy Chain, 10E8-S74W Light Chain, gp41 MPER peptide | Authors: | Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D. | Deposit date: | 2016-03-10 | Release date: | 2016-04-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2869 Å) | Cite: | Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. J.Virol., 90, 2016
|
|
5IQ9
| Crystal structure of 10E8v4 Fab in complex with an HIV-1 gp41 peptide. | Descriptor: | 10E8v4 Heavy Chain, 10E8v4 Light Chain, gp41 MPER peptide | Authors: | Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D. | Deposit date: | 2016-03-10 | Release date: | 2016-04-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. J.Virol., 90, 2016
|
|
4WZ6
| Human CFTR aa389-678 (NBD1), deltaF508 with three solubilizing mutations, bound ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION | Authors: | Byrnes, L.J, Hall, J. | Deposit date: | 2014-11-18 | Release date: | 2015-11-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy. Protein Sci., 25, 2016
|
|
6KYB
| Crystal structure of Atg18 from Saccharomyces cerevisiae | Descriptor: | Autophagy-related protein 18 | Authors: | Tang, D, Lei, Y, Liao, G, Chen, Q, Xu, L, Lu, K, Qi, S. | Deposit date: | 2019-09-17 | Release date: | 2020-09-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The crystal structure of Atg18 reveals a new binding site for Atg2 in Saccharomyces cerevisiae. Cell.Mol.Life Sci., 78, 2021
|
|
7OP1
| Cryo-EM structure of P5B-ATPase E2PiAlF/SPM | Descriptor: | Cation-transporting ATPase, MAGNESIUM ION, SPERMINE, ... | Authors: | Li, P, Gourdon, P. | Deposit date: | 2021-05-28 | Release date: | 2021-06-30 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure and transport mechanism of P5B-ATPases. Nat Commun, 12, 2021
|
|
7OP8
| Cryo-EM structure of P5B-ATPase E2Pinhibit | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Cation-transporting ATPase, MAGNESIUM ION | Authors: | Li, P, Gourdon, P. | Deposit date: | 2021-05-31 | Release date: | 2021-06-30 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure and transport mechanism of P5B-ATPases. Nat Commun, 12, 2021
|
|
7OP5
| Cryo-EM structure of P5B-ATPase E2P | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, P5B-ATPase | Authors: | Li, P, Gourdon, P. | Deposit date: | 2021-05-29 | Release date: | 2021-06-30 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure and transport mechanism of P5B-ATPases. Nat Commun, 12, 2021
|
|
3LGZ
| Crystal structure of dehydrosqualene synthase Y129A from S. aureus complexed with presqualene pyrophosphate | Descriptor: | Dehydrosqualene synthase, MAGNESIUM ION, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | Authors: | Lin, F.-Y, Liu, Y.-L, Liu, C.-I, Wang, A.H.J, Oldfield, E. | Deposit date: | 2010-01-21 | Release date: | 2010-12-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Mechanism of action and inhibition of dehydrosqualene synthase. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
1JW6
| Crystal Structure of the Complex of Concanavalin A and Hexapeptide | Descriptor: | CALCIUM ION, Concanavalin A, ISOPROPYL ALCOHOL, ... | Authors: | Zhang, Z, Qian, M, Huang, Q, Jia, Y, Tang, Y. | Deposit date: | 2001-09-02 | Release date: | 2001-09-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal structure of the complex of concanavalin A and hexapeptide. J.Protein Chem., 20, 2001
|
|
4WXM
| FleQ REC domain from Pseudomonas aeruginosa PAO1 | Descriptor: | Transcriptional regulator FleQ | Authors: | Su, T, Liu, S, Gu, L. | Deposit date: | 2014-11-14 | Release date: | 2015-09-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The REC domain mediated dimerization is critical for FleQ from Pseudomonas aeruginosa to function as a c-di-GMP receptor and flagella gene regulator J.Struct.Biol., 192, 2015
|
|
5B0J
| Structure of MoeN5-Sso7d fusion protein in complex with beta-undecyl maltoside | Descriptor: | MoeN5,DNA-binding protein 7d, UNDECYL-MALTOSIDE | Authors: | Ko, T.-P, Zhang, L, Chen, C.-C, Guo, R.-T, Oldfield, E.O. | Deposit date: | 2015-10-30 | Release date: | 2016-03-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5. Angew.Chem.Int.Ed.Engl., 55, 2016
|
|