4GA3

Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260

Summary for 4GA3

Entry DOI	10.2210/pdb4ga3/pdb
Descriptor	Farnesyl pyrophosphate synthase, 1-butyl-3-(2-hydroxy-2,2-diphosphonoethyl)-1H-imidazol-3-ium, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	all alpha helices, cytosol, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	40621.75
Authors	Liu, Y.-L.,Zhang, Y.,Oldfield, E. (deposition date: 2012-07-24, release date: 2013-05-08, Last modification date: 2023-09-13)
Primary citation	Zhang, Y.,Zhu, W.,Liu, Y.L.,Wang, H.,Wang, K.,Li, K.,No, J.H.,Ayong, L.,Gulati, A.,Pang, R.,Freitas-Junior, L.,Morita, C.T.,Old-Field, E. Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis. ACS MED.CHEM.LETT., 4:423-427, 2013 Cited by PubMed: 23610597 DOI: 10.1021/ml4000436 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.39 Å)

Structure validation