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4FXW
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BU of 4fxw by Molmil
Structure of phosphorylated SF1 complex with U2AF65-UHM domain
Descriptor: SULFATE ION, Splicing factor 1, Splicing factor U2AF 65 kDa subunit
Authors:Wang, W, Bauer, W.J, Wedekind, J.E, Kielkopf, C.L.
Deposit date:2012-07-03
Release date:2013-01-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure of Phosphorylated SF1 Bound to U2AF(65) in an Essential Splicing Factor Complex.
Structure, 21, 2013
6XLX
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BU of 6xlx by Molmil
Crystal structure of cancer-associated G301D mutant of U2AF65 bound to AdML splice site
Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Maji, D, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2020-06-29
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
J.Biol.Chem., 295, 2020
6XLV
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BU of 6xlv by Molmil
Crystal structure of leukemia-associated N196K mutant of U2AF65 bound to AdML splice site
Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Maji, D, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2020-06-29
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
J.Biol.Chem., 295, 2020
3IL2
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BU of 3il2 by Molmil
Crystal structure of a Rex-family repressor R90D mutant/DNA complex from Thermus aquaticus
Descriptor: Redox-sensing transcriptional repressor rex, Rex operator DNA
Authors:McLaughlin, K.J, Kielkopf, C.L.
Deposit date:2009-08-06
Release date:2010-06-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis for NADH/NAD+ redox sensing by a Rex family repressor.
Mol.Cell, 38, 2010
3IKV
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BU of 3ikv by Molmil
Crystal structure of a Rex-family repressor R90D mutant from Thermus aquaticus
Descriptor: CALCIUM ION, Redox-sensing transcriptional repressor rex
Authors:McLaughlin, K.J, Kielkopf, C.L.
Deposit date:2009-08-06
Release date:2010-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for NADH/NAD+ redox sensing by a Rex family repressor.
Mol.Cell, 38, 2010
3IKT
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BU of 3ikt by Molmil
Crystal structure of a Rex-family repressor/DNA/NAD+ complex from Thermus aquaticus
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Redox-sensing transcriptional repressor rex, Rex operator DNA
Authors:McLaughlin, K.J, Kielkopf, C.L.
Deposit date:2009-08-06
Release date:2010-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural basis for NADH/NAD+ redox sensing by a Rex family repressor.
Mol.Cell, 38, 2010
7S3B
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BU of 7s3b by Molmil
Crystal structure of intact U2AF65 RRM-region bound to AdML-G5 oligonucleotide
Descriptor: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*GP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Jenkins, J.L, Henderson, S, Kielkopf, C.L.
Deposit date:2021-09-05
Release date:2022-05-25
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal.
Nucleic Acids Res., 50, 2022
7S3C
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BU of 7s3c by Molmil
Crystal structure of intact U2AF65 RRM-region bound to AdML-A5 oligonucleotide
Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*AP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Glasser, E, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2021-09-05
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal.
Nucleic Acids Res., 50, 2022
5EV1
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BU of 5ev1 by Molmil
Structure I of Intact U2AF65 Recognizing a 3' Splice Site Signal
Descriptor: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(*UP*UP*U)-D(P*UP*UP*(BRU)P*U)-R(P*UP*U)-3'), SODIUM ION, ...
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.037 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV2
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BU of 5ev2 by Molmil
Structure II of Intact U2AF65 Recognizing the 3' Splice Site Signal
Descriptor: 1,4-DIETHYLENE DIOXIDE, DI(HYDROXYETHYL)ETHER, DNA (5'-R(P*UP*U)-D(P*UP*U)-R(P*U)-D(P*UP*(BRU)P*U)-3'), ...
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV3
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BU of 5ev3 by Molmil
Structure III of Intact U2AF65 Recognizing the 3' Splice Site Signal
Descriptor: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU)P*UP*U)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV4
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BU of 5ev4 by Molmil
Structure IV of Intact U2AF65 Recognizing the 3' Splice Site Signal
Descriptor: DNA/RNA (5'-R(P*UP*UP*UP*(UD)P*UP*U)-D(P*(BRU)P*(UD))-R(P*C)-3'), GLYCEROL, Splicing factor U2AF 65 kDa subunit
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
4OZ0
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BU of 4oz0 by Molmil
Crystal structure of human CAPERalpha U2AF homology motif (apo-state)
Descriptor: CHLORIDE ION, RNA-binding protein 39
Authors:Loerch, S, Kielkopf, C.L.
Deposit date:2014-02-13
Release date:2014-05-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cancer-relevant splicing factor CAPER alpha engages the essential splicing factor SF3b155 in a specific ternary complex.
J.Biol.Chem., 289, 2014
4OZ1
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BU of 4oz1 by Molmil
Crystal structure of human CAPERalpha UHM bound to SF3b155 ULM5
Descriptor: CHLORIDE ION, LYSINE, POTASSIUM ION, ...
Authors:Loerch, S, Kielkopf, C.L.
Deposit date:2014-02-13
Release date:2014-05-14
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Cancer-relevant splicing factor CAPER alpha engages the essential splicing factor SF3b155 in a specific ternary complex.
J.Biol.Chem., 289, 2014
4TU9
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BU of 4tu9 by Molmil
STRUCTURE OF U2AF65 VARIANT WITH BRU5G6 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*DG*U)-3'), GLYCEROL, ...
Authors:Jenkins, J.L, McLaughlin, K.J, Agrawal, A.A, Kielkopf, C.L.
Deposit date:2014-06-24
Release date:2014-11-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.992 Å)
Cite:Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TU8
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BU of 4tu8 by Molmil
STRUCTURE OF U2AF65 VARIANT WITH BRU5A6 DNA
Descriptor: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*DA*U)-3'), ...
Authors:MCLAUGHLIN, K.J, JENKINS, J.L, Agrawal, A.A, KIELKOPF, C.L.
Deposit date:2014-06-24
Release date:2014-11-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.918 Å)
Cite:Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TU7
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BU of 4tu7 by Molmil
Structure of U2AF65 D231V variant with BrU5 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*UP*U)-3'), GLYCEROL, ...
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2014-06-24
Release date:2014-11-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.087 Å)
Cite:Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.
Proc.Natl.Acad.Sci.USA, 111, 2014
3BS9
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BU of 3bs9 by Molmil
X-ray structure of human TIA-1 RRM2
Descriptor: IODIDE ION, Nucleolysin TIA-1 isoform p40
Authors:Kumar, A.O, Kielkopf, C.L.
Deposit date:2007-12-22
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution.
Biochem.Biophys.Res.Commun., 367, 2008
3CGR
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BU of 3cgr by Molmil
X-ray structure containing the pseudouridylated U2 snRNA and intron branch site consensus sequences
Descriptor: RNA (5'-R(*CP*GP*CP*AP*CP*UP*AP*AP*CP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*GP*(PSU)P*AP*GP*UP*GP*C)-3'), SULFATE ION
Authors:Lin, Y, Kielkopf, C.L.
Deposit date:2008-03-06
Release date:2008-07-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGP
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BU of 3cgp by Molmil
X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex bound to iodide ions
Descriptor: IODIDE ION, RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*AP*AP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3'), ...
Authors:Lin, Y, Kielkopf, C.L.
Deposit date:2008-03-06
Release date:2008-07-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGQ
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BU of 3cgq by Molmil
X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex
Descriptor: RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*AP*AP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3'), SULFATE ION
Authors:Lin, Y, Kielkopf, C.L.
Deposit date:2008-03-06
Release date:2008-07-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGS
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BU of 3cgs by Molmil
X-ray structure containing the pseudouridylated U2 snRNA and mammalian intron branch site consensus sequences
Descriptor: MAGNESIUM ION, RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*GP*AP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3')
Authors:Lin, Y, Kielkopf, C.L.
Deposit date:2008-03-06
Release date:2008-07-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3VAG
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BU of 3vag by Molmil
Structure of U2AF65 variant with BrU3C2 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA 5'-D(*U*CP*(BRU)P*UP*UP*UP*U)-3', GLYCEROL, ...
Authors:Jenkins, J.L, Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAH
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BU of 3vah by Molmil
Structure of U2AF65 variant with BrU3C4 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA 5'-D(P*UP*UP*(BRU)P*CP*UP*UP*U)-3', GLYCEROL, ...
Authors:Jenkins, J.L, Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAL
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BU of 3val by Molmil
Structure of U2AF65 variant with BrU5C1 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*C*UP*UP*UP*(BRU)P*UP*U)-3'), SULFATE ION, ...
Authors:Jenkins, J.L, Frato, K.H, Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013

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