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7JK1
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BU of 7jk1 by Molmil
Human PrimPol inserting correct dCTP opposite the 8-oxoguanine lesion
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Rechkoblit, O, Aggarwal, A.K.
Deposit date:2020-07-27
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Nat Commun, 12, 2021
7JKP
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BU of 7jkp by Molmil
Human PrimPol misinserting dATP opposite the 8-oxoguanine lesion
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*CP*G)-3'), ...
Authors:Rechkoblit, O, Aggarwal, A.K.
Deposit date:2020-07-28
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.592 Å)
Cite:Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Nat Commun, 12, 2021
7JKL
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BU of 7jkl by Molmil
Human PrimPol misinserting dATP opposite the 8-oxoguanine lesion (3'-end base of the primer strand is 2',3'-dideoxy-terminated).
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*CP*(DDG))-3'), ...
Authors:Rechkoblit, O, Aggarwal, A.K.
Deposit date:2020-07-28
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.384 Å)
Cite:Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Nat Commun, 12, 2021
7JL8
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BU of 7jl8 by Molmil
Human PrimPol extending from the correct primer base C opposite the 8-oxoguanine lesion
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, ...
Authors:Rechkoblit, O, Aggarwal, A.K.
Deposit date:2020-07-29
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Nat Commun, 12, 2021
7JLG
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BU of 7jlg by Molmil
Human PrimPol extending from the erroneous primer base A opposite the 8-oxoguanine lesion
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Rechkoblit, O, Aggarwal, A.K.
Deposit date:2020-07-29
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Nat Commun, 12, 2021
2OH2
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BU of 2oh2 by Molmil
Ternary Complex of Human DNA Polymerase
Descriptor: 5'-D(*GP*GP*G*GP*GP*AP*AP*GP*GP*AP*CP*CP*C)-3', 5'-D(*TP*T*CP*CP*AP*GP*GP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', DNA polymerase kappa, ...
Authors:Lone, S, Townson, S.A, Uljon, S.N, Prakash, S, Prakash, L, Aggarwal, A.K.
Deposit date:2007-01-09
Release date:2007-02-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Ternary complex of the catalytic core of human DNA polymerase Kappa with DNA and dTT
To be Published
2OO8
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BU of 2oo8 by Molmil
Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors
Descriptor: Angiopoietin-1 receptor, N-{3-[3-(DIMETHYLAMINO)PROPYL]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]BENZAMIDE
Authors:Bellon, S.F, Kim, J.
Deposit date:2007-01-25
Release date:2007-03-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
5ULX
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BU of 5ulx by Molmil
Structure of human DNA polymerase iota bound to template 1-methyl-deoxyadenosine crystallized in the presence of dCTP
Descriptor: CHLORIDE ION, DNA (5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3'), DNA (5'-D(P*(MA7)P*GP*GP*GP*TP*CP*CP*T)-3'), ...
Authors:Jain, R, Aggarwal, A.K.
Deposit date:2017-01-25
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota.
Sci Rep, 7, 2017
5ULW
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BU of 5ulw by Molmil
Structure of human DNA polymerase iota bound to template 1-methyl-deoxyadenosine
Descriptor: CHLORIDE ION, DNA (5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3'), DNA (5'-D(*TP*(MA7)P*GP*GP*GP*TP*CP*CP*T)-3'), ...
Authors:Jain, R, Aggarwal, A.K.
Deposit date:2017-01-25
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.617 Å)
Cite:Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota.
Sci Rep, 7, 2017
1ZET
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BU of 1zet by Molmil
X-ray data do not support hoogsteen base-pairing during replication by human polymerase iota
Descriptor: 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(P*AP*GP*GP*GP*(BRU)P*CP*CP*(BRU)P*(BRU)P*CP*CP*CP*CP*C)-3', MAGNESIUM ION, ...
Authors:Wang, J.
Deposit date:2005-04-19
Release date:2005-07-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:DNA polymerases: Hoogsteen base-pairing in DNA replication?
Nature, 437, 2005
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