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4ATZ
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BU of 4atz by Molmil
Ad5 knob in complex with a designed ankyrin repeat protein
Descriptor: DESIGNED ANKYRIN REPEAT PROTEIN, Fiber protein
Authors:Mittl, P.R.E, Hess, C, Dreier, B.
Deposit date:2012-05-11
Release date:2013-02-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4HRN
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BU of 4hrn by Molmil
Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2
Descriptor: Designed Ankyrin Repeat Protein H10-2-G, Receptor tyrosine-protein kinase erbB-2
Authors:Jost, C, Schilling, J, Plueckthun, A.
Deposit date:2012-10-28
Release date:2013-10-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2.
Structure, 21, 2013
4HRL
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BU of 4hrl by Molmil
Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2
Descriptor: Designed Ankyrin Repeat Protein 9_29, Receptor tyrosine-protein kinase erbB-2
Authors:Jost, C, Schilling, J, Plueckthun, A.
Deposit date:2012-10-28
Release date:2013-10-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2.
Structure, 21, 2013
4HRM
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BU of 4hrm by Molmil
Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2
Descriptor: Designed Ankyrin Repeat Protein 9_26, Domain I of receptor tyrosine-protein kinase erbB-2
Authors:Jost, C, Schilling, J, Plueckthun, A.
Deposit date:2012-10-28
Release date:2013-10-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2.
Structure, 21, 2013
6Z4Q
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BU of 6z4q by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small-molecule inverse agonist SR142948A
Descriptor: 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methyl-carbamoyl]-2-propan-2-yl-phenyl]pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
Authors:Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
Deposit date:2020-05-25
Release date:2021-02-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.923 Å)
Cite:Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6YVR
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BU of 6yvr by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the peptide full agonist NTS8-13
Descriptor: Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin crystallisation chaperone, neurotensin NTS8-13 (full agonist), nonyl beta-D-glucopyranoside
Authors:Deluigi, M, Merklinger, L, Hilge, M, Ernst, P, Klipp, A, Klenk, C, Plueckthun, A.
Deposit date:2020-04-28
Release date:2021-02-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.458 Å)
Cite:Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z4S
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BU of 6z4s by Molmil
Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with the small molecule inverse agonist SR48692
Descriptor: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence
Authors:Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
Deposit date:2020-05-25
Release date:2021-02-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.707 Å)
Cite:Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6ZIN
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BU of 6zin by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small molecule inverse agonist SR48692
Descriptor: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence
Authors:Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
Deposit date:2020-06-26
Release date:2021-02-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.639 Å)
Cite:Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z66
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BU of 6z66 by Molmil
Crystal structure of apo-state neurotensin receptor 1
Descriptor: Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
Authors:Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
Deposit date:2020-05-27
Release date:2021-02-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.192 Å)
Cite:Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z8N
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BU of 6z8n by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small-molecule full agonist SRI-9829
Descriptor: (2~{S})-4-methyl-2-[(1-quinolin-8-ylsulfonylindol-3-yl)carbonylamino]pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1)
Authors:Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
Deposit date:2020-06-02
Release date:2021-02-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6ZA8
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BU of 6za8 by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small-molecule partial agonist RTI-3a
Descriptor: (2~{S})-2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]-4-methyl-pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1),Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1)
Authors:Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
Deposit date:2020-06-05
Release date:2021-02-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z4V
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BU of 6z4v by Molmil
Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with NTS8-13
Descriptor: ARG-PRO-TYR-ILE-LEU, Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
Authors:Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
Deposit date:2020-05-25
Release date:2021-02-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
5LE2
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BU of 5le2 by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DDD_D12_15_D12_15_D12
Descriptor: ACETATE ION, DDD_D12_15_D12_15_D12, THIOCYANATE ION
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-29
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LEC
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BU of 5lec by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DDD_D12_12_D12_12_D12
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DDD_D12_12_D12_12_D12
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-29
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LEL
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BU of 5lel by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_10_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein
Descriptor: DD_Off7_10_3G124, Green fluorescent protein, Maltose-binding periplasmic protein
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-30
Release date:2017-11-15
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LE9
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BU of 5le9 by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_09_3G124
Descriptor: ACETATE ION, DD_Off7_09_3G124
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-29
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LEE
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BU of 5lee by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DDD_D12_12_D12_12_D12
Descriptor: DDD_D12_12_D12_12_D12
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-29
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LE8
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BU of 5le8 by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_15_D12
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DD_D12_15_D12, GLYCEROL, ...
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-29
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LE7
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BU of 5le7 by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_13_D12
Descriptor: DD_D12_13_D12, SULFATE ION
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-29
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LW2
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BU of 5lw2 by Molmil
Crystal structure of DARPin 5m3_D12
Descriptor: ACETATE ION, DARPin_5m3_D12
Authors:Batyuk, A, Wu, Y, Plueckthun, A.
Deposit date:2016-09-15
Release date:2017-09-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LE3
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BU of 5le3 by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_09_D12
Descriptor: DD_D12_09_D12
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-29
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LEB
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BU of 5leb by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DDD_D12_06_D12_06_D12
Descriptor: DDD_D12_06_D12_06_D12
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-29
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LE4
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BU of 5le4 by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_11_D12
Descriptor: DD_D12_11_D12
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-29
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LEA
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BU of 5lea by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_12_3G124
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, DD_Off7_12_3G124
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-29
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LED
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BU of 5led by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DDD_D12_12_D12_12_D12
Descriptor: DDD_D12_12_D12_12_D12
Authors:Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
Deposit date:2016-06-29
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017

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