4HRM

Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2

Summary for 4HRM

Entry DOI	10.2210/pdb4hrm/pdb
Related	1N8Z 1S78 3H3B 3MZW 4HRL 4HRN
Descriptor	Domain I of receptor tyrosine-protein kinase erbB-2, Designed Ankyrin Repeat Protein 9_26 (2 entities in total)
Functional Keywords	transferase-de novo protein complex, transferase/de novo protein
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
Total number of polymer chains	4
Total formula weight	81712.63
Authors	Jost, C.,Schilling, J.,Plueckthun, A. (deposition date: 2012-10-28, release date: 2013-10-16, Last modification date: 2023-11-08)
Primary citation	Jost, C.,Schilling, J.,Tamaskovic, R.,Schwill, M.,Honegger, A.,Plueckthun, A. Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2. Structure, 21:1-13, 2013 Cited by PubMed: 24095059 DOI: 10.1016/j.str.2013.08.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation