7LD5
| polynucleotide phosphorylase | Descriptor: | MAGNESIUM ION, Polyribonucleotide nucleotidyltransferase, poly-A RNA fragment | Authors: | Goldgur, Y, Shuman, S, De La Cruz, M.J, Ghosh, S, Unciuleac, M.-C. | Deposit date: | 2021-01-12 | Release date: | 2021-06-30 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structure and mechanism of Mycobacterium smegmatis polynucleotide phosphorylase. Rna, 27, 2021
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6U05
| Crystal Structure of Fungal RNA Kinase | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Shuman, S, Goldgur, Y, Banerjee, A. | Deposit date: | 2019-08-13 | Release date: | 2019-11-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.948 Å) | Cite: | Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor. Nucleic Acids Res., 47, 2019
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7MQW
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1PYS
| PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS | Descriptor: | MAGNESIUM ION, PHENYLALANYL-TRNA SYNTHETASE | Authors: | Safro, M, Mosyak, L, Goldgur, Y, Reshetnikova, L, Delarue, M. | Deposit date: | 1996-11-14 | Release date: | 1997-11-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus. Nat.Struct.Biol., 2, 1995
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2V0Y
| Crystal structure of apo C298S tryptophanase from E.coli | Descriptor: | CHLORIDE ION, MAGNESIUM ION, TRYPTOPHANASE | Authors: | Kogan, A, Gdalevsky, G.Y, Cohen-Luria, R, Goldgur, Y, Parola, A.H, Almog, O. | Deposit date: | 2007-05-21 | Release date: | 2008-06-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational Changes and Loose Packing Promote E. Coli Tryptophanase Cold Lability. Bmc Struct.Biol., 9, 2009
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2V1P
| Crystal Structure of the apo form of Y74F mutant E. coli tryptophanase | Descriptor: | CHLORIDE ION, MAGNESIUM ION, TRYPTHOPANASE | Authors: | Kogan, A, Gdalevsky, G.Y, Cohen-Luria, R, Goldgur, Y, Parola, A.H, Almog, O. | Deposit date: | 2007-05-28 | Release date: | 2008-06-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Conformational Changes and Loose Packing Promote E. Coli Tryptophanase Cold Lability. Bmc Struct.Biol., 9, 2009
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5HFZ
| Mmi1 YTH domain | Descriptor: | YTH domain-containing protein mmi1 | Authors: | Chatterjee, D, Goldgur, Y, Shuman, S. | Deposit date: | 2016-01-07 | Release date: | 2016-02-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. Rna, 22, 2016
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5H8A
| Mmi1 YTH domain | Descriptor: | YTH domain-containing protein mmi1 | Authors: | Chatterjee, D, Goldgur, Y, Shuman, S. | Deposit date: | 2015-12-23 | Release date: | 2016-01-13 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. Rna, 22, 2016
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3G5P
| Structure and activity of human mitochondrial peptide deformylase, a novel cancer target | Descriptor: | COBALT (II) ION, PHOSPHATE ION, Peptide deformylase, ... | Authors: | Escobar-Alvarez, S, Goldgur, Y, Yang, G, Ouerfelli, O, Li, Y, Scheinberg, D.A. | Deposit date: | 2009-02-05 | Release date: | 2009-04-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and activity of human mitochondrial peptide deformylase, a novel cancer target J.Mol.Biol., 387, 2009
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3G5K
| Structure and activity of human mitochondrial peptide deformylase, a novel cancer target | Descriptor: | ACTINONIN, COBALT (II) ION, Peptide deformylase, ... | Authors: | Escobar-Alvarez, S, Goldgur, Y, Yang, G, Ouerfelli, O, Li, Y, Scheinberg, D.A. | Deposit date: | 2009-02-05 | Release date: | 2009-04-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and activity of human mitochondrial peptide deformylase, a novel cancer target J.Mol.Biol., 387, 2009
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4M4R
| Epha4 ectodomain complex with ephrin a5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-A receptor 4, ... | Authors: | Xu, K, Tsvetkova-Robev, D, Xu, Y, Goldgur, Y, Chan, Y.-P, Himanen, J.P, Nikolov, D.B. | Deposit date: | 2013-08-07 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proc.Natl.Acad.Sci.USA, 110, 2013
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4M4P
| Crystal structure of EPHA4 ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-A receptor 4 | Authors: | Xu, K, Tsvetkova-Robev, D, Xu, Y, Goldgur, Y, Chan, Y.-P, Himanen, J.P, Nikolov, D.B. | Deposit date: | 2013-08-07 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.081 Å) | Cite: | Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proc.Natl.Acad.Sci.USA, 110, 2013
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8GH4
| Complex of Adam 10 disentegrin cysteine rich domains with human monoclonal antibody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody heavy chain, Antibody light chain, ... | Authors: | Nikolov, D.B, Saha, N, Xu, K, Goldgur, Y. | Deposit date: | 2023-03-09 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells. Biomed Pharmacother, 161, 2023
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6EDE
| tRNA 2'-phosphotransferase | Descriptor: | Probable RNA 2'-phosphotransferase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate | Authors: | Shuman, S, Goldgur, Y, Banerjee, A. | Deposit date: | 2018-08-09 | Release date: | 2019-03-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.553 Å) | Cite: | Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO4recognition and ADP-ribosylation. Nat Commun, 10, 2019
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6E33
| Crystal Structure of Pho7-DNA complex | Descriptor: | DNA (5'-D(*GP*AP*TP*TP*TP*GP*AP*AP*TP*GP*TP*CP*CP*GP*AP*AP*GP*GP*AP*T)-3'), DNA (5'-D(*TP*CP*CP*TP*TP*CP*GP*GP*AP*CP*AP*TP*TP*CP*AP*AP*AP*TP*CP*A)-3'), Uncharacterized transcriptional regulatory protein C27B12.11c, ... | Authors: | Garg, A, Goldgur, Y, Shuman, S. | Deposit date: | 2018-07-13 | Release date: | 2018-10-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.705 Å) | Cite: | Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis. Nucleic Acids Res., 46, 2018
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6E3A
| tRNA 2'-phosphotransferase | Descriptor: | COENZYME A, Probable RNA 2'-phosphotransferase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate | Authors: | Shuman, S, Goldgur, Y, Banerjee, A. | Deposit date: | 2018-07-13 | Release date: | 2019-03-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO4recognition and ADP-ribosylation. Nat Commun, 10, 2019
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6NHX
| mycobacterial DNA ligase D complexed with ATP and MES | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent DNA ligase | Authors: | Shuman, S, Unciuleac, M, Goldgur, Y. | Deposit date: | 2018-12-24 | Release date: | 2019-02-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates. J. Biol. Chem., 294, 2019
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6NHZ
| mycobacterial DNA ligase D complexed with ATP and Mg | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent DNA ligase, MAGNESIUM ION | Authors: | Shuman, S, Unciuleac, M, Goldgur, Y. | Deposit date: | 2018-12-24 | Release date: | 2019-02-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates. J. Biol. Chem., 294, 2019
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6O19
| Crystal Structure of Pho7 complex with pho1 promoter site 2 | Descriptor: | DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*AP*TP*TP*TP*CP*CP*GP*AP*AP*TP*AP*AP*T)-3'), DNA (5'-D(*TP*TP*AP*TP*TP*CP*GP*GP*AP*AP*AP*TP*TP*AP*AP*AP*AP*AP*CP*A)-3'), Transcription factor Pho7, ... | Authors: | Garg, A, Goldgur, Y, Shuman, S. | Deposit date: | 2019-02-18 | Release date: | 2019-04-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.596 Å) | Cite: | Structure of Fission Yeast Transcription Factor Pho7 Bound topho1Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis. Mol.Cell.Biol., 39, 2019
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5U32
| Crystal Structure of Fungal RNA Kinase | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, tRNA ligase | Authors: | Shuman, S, Goldgur, Y, Remus, B.S. | Deposit date: | 2016-12-01 | Release date: | 2017-11-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.191 Å) | Cite: | Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase. Nucleic Acids Res., 45, 2017
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3VFG
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4JYO
| Structural basis for angiopoietin-1 mediated signaling initiation | Descriptor: | Angiopoietin-1, CALCIUM ION | Authors: | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | Deposit date: | 2013-03-31 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4JZC
| Angiopoietin-2 fibrinogen domain TAG mutant | Descriptor: | Angiopoietin-2 | Authors: | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | Deposit date: | 2013-04-02 | Release date: | 2013-05-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4K0V
| Structural basis for angiopoietin-1 mediated signaling initiation | Descriptor: | Angiopoietin-1, TEK tyrosine kinase variant | Authors: | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | Deposit date: | 2013-04-04 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4.51 Å) | Cite: | Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
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3HEI
| Ligand Recognition by A-Class Eph Receptors: Crystal Structures of the EphA2 Ligand-Binding Domain and the EphA2/ephrin-A1 Complex | Descriptor: | Ephrin type-A receptor 2, Ephrin-A1 | Authors: | Himanen, J.P, Goldgur, Y, Miao, H, Myshkin, E, Guo, H, Buck, M, Nguyen, M, Rajashankar, K.R, Wang, B, Nikolov, D.B. | Deposit date: | 2009-05-08 | Release date: | 2009-06-30 | Last modified: | 2021-03-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. Embo Rep., 10, 2009
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