7Z52
| Human NEXT dimer - focused reconstruction of the single MTR4 | Descriptor: | Exosome RNA helicase MTR4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*UP*UP*UP*UP*U)-3'), ... | Authors: | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | Deposit date: | 2022-03-07 | Release date: | 2022-06-22 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
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6Z3R
| Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Langer, L.M, Gat, Y, Conti, E. | Deposit date: | 2020-05-21 | Release date: | 2020-06-24 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity. Elife, 9, 2020
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5JNB
| structure of GLD-2/RNP-8 complex | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Poly(A) RNA polymerase gld-2, ... | Authors: | Nakel, K, Bonneau, F, Basquin, C, Eckmann, C.R, Conti, E. | Deposit date: | 2016-04-29 | Release date: | 2016-06-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.486 Å) | Cite: | Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity. Rna, 22, 2016
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1FT8
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7AQO
| yeast THO-Sub2 complex dimer | Descriptor: | BJ4_G0025130.mRNA.1.CDS.1, EM14S01-3B_G0007820.mRNA.1.CDS.1, TEX1 isoform 1, ... | Authors: | Schuller, S.K, Schuller, J.M, Prabu, R.J, Baumgartner, M, Bonneau, F, basquin, J, Conti, E. | Deposit date: | 2020-10-22 | Release date: | 2020-12-02 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. Elife, 9, 2020
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1FO1
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7APX
| yeast THO-Sub2 complex | Descriptor: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2,Tho2, ... | Authors: | Schuller, S.K, Schuller, J.M, Prabu, R.J, Baumgartner, M, Bonneau, F, basquin, J, Conti, E. | Deposit date: | 2020-10-20 | Release date: | 2020-12-02 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. Elife, 9, 2020
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4IFD
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4JHK
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5LXR
| Structure of the minimal RBM7 - ZCCHC8 Complex | Descriptor: | BROMIDE ION, CHLORIDE ION, RNA-binding protein 7, ... | Authors: | Falk, S, Finogenova, K, Benda, C, Conti, E. | Deposit date: | 2016-09-22 | Release date: | 2016-12-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. Nat Commun, 7, 2016
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5LXY
| Structure of the minimal RBM7 - ZCCHC8 Complex | Descriptor: | BROMIDE ION, RNA-binding protein 7, Zinc finger CCHC domain-containing protein 8 | Authors: | Falk, S, Finogenova, K, Benda, C, Conti, E. | Deposit date: | 2016-09-23 | Release date: | 2016-12-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. Nat Commun, 7, 2016
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4JHJ
| Crystal structure of Danio rerio Slip1 in complex with Dbp5 | Descriptor: | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast), MIF4G domain-containing protein B | Authors: | Von Moeller, H, Conti, E. | Deposit date: | 2013-03-05 | Release date: | 2013-07-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins. Nucleic Acids Res., 41, 2013
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1RK8
| Structure of the cytosolic protein PYM bound to the Mago-Y14 core of the exon junction complex | Descriptor: | CALCIUM ION, CG8781-PA protein, Mago nashi protein, ... | Authors: | Bono, F, Ebert, J, Guettler, T, Izaurralde, E, Conti, E. | Deposit date: | 2003-11-21 | Release date: | 2004-04-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular insights into the interaction of PYM with
the Mago-Y14 core of the exon junction complex EMBO Rep., 5, 2004
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6R5K
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6RO1
| X-ray crystal structure of the MTR4 NVL complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Exosome RNA helicase MTR4, ... | Authors: | Lingaraju, M, Langer, L.M, Basquin, J, Falk, S, Conti, E. | Deposit date: | 2019-05-10 | Release date: | 2019-07-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs. Nat Commun, 10, 2019
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2C37
| RNASE PH CORE OF THE ARCHAEAL EXOSOME IN COMPLEX WITH U8 RNA | Descriptor: | 5-O-phosphono-beta-D-ribofuranose, CHLORIDE ION, PROBABLE EXOSOME COMPLEX EXONUCLEASE 1, ... | Authors: | Lorentzen, E, Conti, E. | Deposit date: | 2005-10-04 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core. Mol.Cell, 20, 2005
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2C38
| RNase PH core of the archaeal exosome in complex with A5 RNA | Descriptor: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, PROBABLE EXOSOME COMPLEX EXONUCLEASE 1, ... | Authors: | Lorentzen, E, Conti, E. | Deposit date: | 2005-10-04 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core. Mol.Cell, 20, 2005
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2C39
| RNase PH core of the archaeal exosome in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PROBABLE EXOSOME COMPLEX EXONUCLEASE 1, PROBABLE EXOSOME COMPLEX EXONUCLEASE 2 | Authors: | Lorentzen, E, Conti, E. | Deposit date: | 2005-10-05 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core. Mol.Cell, 20, 2005
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7QDS
| Apo human SKI complex in the open state | Descriptor: | Helicase SKI2W, Tetratricopeptide repeat protein 37, WD repeat-containing protein 61 | Authors: | Koegel, A, Keidel, A, Bonneau, A, Schaefer, I.B, Conti, E. | Deposit date: | 2021-11-30 | Release date: | 2022-02-02 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Mol.Cell, 82, 2022
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7QDR
| Apo human SKI complex in the closed state | Descriptor: | Helicase SKI2W, Tetratricopeptide repeat protein 37, WD repeat-containing protein 61 | Authors: | Koegel, A, Keidel, A, Bonneau, F, Schaefer, I.B, Conti, E. | Deposit date: | 2021-11-29 | Release date: | 2022-02-02 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Mol.Cell, 82, 2022
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7QE0
| 80S-bound human SKI complex in the open state | Descriptor: | Helicase SKI2W, RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') | Authors: | Koegel, A, Keidel, A, Bonneau, F, Schaefer, I.B, Conti, E. | Deposit date: | 2021-12-01 | Release date: | 2022-02-09 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Mol.Cell, 82, 2022
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7QDZ
| 80S-bound human SKI complex in the closed state | Descriptor: | Helicase SKI2W, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3'), Tetratricopeptide repeat protein 37, ... | Authors: | Koegel, A, Keidel, A, Bonneau, F, Schaefer, I.B, Conti, E. | Deposit date: | 2021-12-01 | Release date: | 2022-02-09 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Mol.Cell, 82, 2022
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7QDY
| RNA-bound human SKI complex | Descriptor: | Helicase SKI2W, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3'), Tetratricopeptide repeat protein 37, ... | Authors: | Koegel, A, Keidel, A, Bonneau, F, Schaefer, I.B, Conti, E. | Deposit date: | 2021-12-01 | Release date: | 2022-02-09 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Mol.Cell, 82, 2022
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1A0C
| XYLOSE ISOMERASE FROM THERMOANAEROBACTERIUM THERMOSULFURIGENES | Descriptor: | COBALT (II) ION, XYLOSE ISOMERASE | Authors: | Gallay, O, Chopra, R, Conti, E, Brick, P, Blow, D. | Deposit date: | 1997-11-28 | Release date: | 1998-06-03 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structures of Class II Xylose Isomerases from Two Thermophiles and a Hyperthermophile To be Published
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1A0D
| XYLOSE ISOMERASE FROM BACILLUS STEAROTHERMOPHILUS | Descriptor: | MANGANESE (II) ION, XYLOSE ISOMERASE | Authors: | Gallay, O, Chopra, R, Conti, E, Brick, P, Blow, D. | Deposit date: | 1997-11-28 | Release date: | 1998-06-03 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal Structures of Class II Xylose Isomerases from Two Thermophiles and a Hyperthermophile To be Published
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