4LVG
| Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | (1S,2S)-N-[4-(phenylsulfonyl)phenyl]-2-(pyridin-3-yl)cyclopropanecarboxamide, 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, ... | Authors: | Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. | Deposit date: | 2013-07-26 | Release date: | 2013-09-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.702 Å) | Cite: | Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
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4M6Q
| Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1-(5-O-phosphono-beta-D-ribofuranosyl)-N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, ... | Authors: | Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. | Deposit date: | 2013-08-10 | Release date: | 2013-09-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.406 Å) | Cite: | Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
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4M6P
| Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | N-[4-(phenylsulfonyl)benzyl]-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | Authors: | Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. | Deposit date: | 2013-08-10 | Release date: | 2013-09-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
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2KHS
| Solution structure of SNase121:SNase(111-143) complex | Descriptor: | Nuclease, Thermonuclease | Authors: | Geng, Y, Feng, Y, Xie, T, Shan, L, Wang, J. | Deposit date: | 2009-04-10 | Release date: | 2009-10-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The native-like interactions between SNase121 and SNase(111-143) fragments induce the recovery of their native-like structures and the ability to degrade DNA. Biochemistry, 48, 2009
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3ORW
| Crystal structure of thermophilic phosphotriesterase from Geobacillus kaustophilus HTA426 | Descriptor: | COBALT (II) ION, Phosphotriesterase | Authors: | Zheng, B.S, Yu, S.S, Zhang, Y, Lou, Z.Y, Feng, Y. | Deposit date: | 2010-09-07 | Release date: | 2011-09-21 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of thermophilic phosphotriesterase from Geobacillus kaustophilus HTA426 To be Published
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4K6H
| Crystal structure of CALB mutant L278M from Candida antarctica | Descriptor: | 1,2-ETHANEDIOL, Lipase B | Authors: | An, J, Xie, Y, Feng, Y, Wu, G. | Deposit date: | 2013-04-15 | Release date: | 2014-01-29 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Enhanced enzyme kinetic stability by increasing rigidity within the active site. J.Biol.Chem., 289, 2014
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4K5Q
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4K6K
| Crystal structure of CALB mutant D223G from Candida antarctica | Descriptor: | 1,2-ETHANEDIOL, Lipase B | Authors: | An, J, Xie, Y, Feng, Y, Wu, G. | Deposit date: | 2013-04-16 | Release date: | 2014-01-29 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Enhanced enzyme kinetic stability by increasing rigidity within the active site. J.Biol.Chem., 289, 2014
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4F1Z
| Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB | Descriptor: | Clumping factor B, MAGNESIUM ION, peptide from Keratin, ... | Authors: | Yang, M.J, Xiang, H, Wang, J.W, Liu, B, Chen, Y.G, Liu, L, Deng, X.M, Feng, Y. | Deposit date: | 2012-05-07 | Release date: | 2012-08-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB Plos Pathog., 8, 2012
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4F24
| Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB | Descriptor: | Clumping factor B, MAGNESIUM ION | Authors: | Yang, M.J, Xiang, H, Wang, J.W, Liu, B, Chen, Y.G, Liu, L, Deng, X.M, Feng, Y. | Deposit date: | 2012-05-07 | Release date: | 2012-08-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.509 Å) | Cite: | Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB Plos Pathog., 8, 2012
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4F27
| Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB | Descriptor: | Clumping factor B, MAGNESIUM ION, peptide from Fibrinogen alpha chain | Authors: | Yang, M.J, Xiang, H, Wang, J.W, Liu, B, Chen, Y.G, Liu, L, Deng, X.M, Feng, Y. | Deposit date: | 2012-05-07 | Release date: | 2012-08-08 | Last modified: | 2015-02-04 | Method: | X-RAY DIFFRACTION (1.917 Å) | Cite: | Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB Plos Pathog., 8, 2012
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4K6G
| Crystal structure of CALB from Candida antarctica | Descriptor: | 1,2-ETHANEDIOL, Lipase B | Authors: | An, J, Xie, Y, Feng, Y, Wu, G. | Deposit date: | 2013-04-15 | Release date: | 2014-01-29 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Enhanced enzyme kinetic stability by increasing rigidity within the active site. J.Biol.Chem., 289, 2014
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3RJY
| Crystal Structure of Hyperthermophilic Endo-beta-1,4-glucanase in complex with substrate | Descriptor: | Endoglucanase FnCel5A, PHOSPHATE ION, alpha-D-glucopyranose | Authors: | Zheng, B, Yang, W, Zhao, X, Wang, Y, Lou, Z, Rao, Z, Feng, Y. | Deposit date: | 2011-04-15 | Release date: | 2012-02-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of hyperthermophilic Endo-beta-1,4-glucanase: Implications for catalytic mechanism and thermostability. J.Biol.Chem., 287, 2012
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4F20
| Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB | Descriptor: | Clumping factor B, MAGNESIUM ION, peptide from Dermokine | Authors: | Yang, M.J, Xiang, H, Wang, J.W, Liu, B, Chen, Y.G, Liu, L, Deng, X.M, Feng, Y. | Deposit date: | 2012-05-07 | Release date: | 2012-08-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB Plos Pathog., 8, 2012
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2MDT
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1VE7
| Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1 in complex with p-nitrophenyl phosphate | Descriptor: | 4-NITROPHENYL PHOSPHATE, Acylamino-acid-releasing enzyme, GLYCEROL | Authors: | Bartlam, M, Wang, G, Gao, R, Yang, H, Zhao, X, Xie, G, Cao, S, Feng, Y, Rao, Z. | Deposit date: | 2004-03-27 | Release date: | 2004-11-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1 STRUCTURE, 12, 2004
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1VE6
| Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1 | Descriptor: | Acylamino-acid-releasing enzyme, GLYCEROL, octyl beta-D-glucopyranoside | Authors: | Bartlam, M, Wang, G, Gao, R, Yang, H, Zhao, X, Xie, G, Cao, S, Feng, Y, Rao, Z. | Deposit date: | 2004-03-27 | Release date: | 2004-11-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1 STRUCTURE, 12, 2004
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2MTE
| Solution structure of Doc48S | Descriptor: | CALCIUM ION, Cellulose 1,4-beta-cellobiosidase (reducing end) CelS | Authors: | Chen, C, Feng, Y. | Deposit date: | 2014-08-18 | Release date: | 2014-10-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Revisiting the NMR solution structure of the Cel48S type-I dockerin module from Clostridium thermocellum reveals a cohesin-primed conformation. J.Struct.Biol., 188, 2014
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3RJX
| Crystal Structure of Hyperthermophilic Endo-Beta-1,4-glucanase | Descriptor: | Endoglucanase FnCel5A | Authors: | Zheng, B.S, Yang, W, Zhao, X.Y, Wang, Y.G, Lou, Z.Y, Rao, Z.H, Feng, Y. | Deposit date: | 2011-04-15 | Release date: | 2011-12-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of hyperthermophilic endo-beta-1,4-glucanase: implications for catalytic mechanism and thermostability. J.Biol.Chem., 287, 2012
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5ULL
| CLOSTRIDIUM BEIJERINCKII FLAVODOXIN: REDUCED | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | Authors: | Ludwig, M.L, Pattridge, K.A, Metzger, A.L, Dixon, M.M, Eren, M, Feng, Y, Swenson, R. | Deposit date: | 1997-01-09 | Release date: | 1997-03-12 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes. Biochemistry, 36, 1997
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5VFK
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8JCX
| Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode II) | Descriptor: | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JD0
| Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of NAM563 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(1-methylpyrazol-4-yl)-7-[[(2~{S})-2-(trifluoromethyl)morpholin-4-yl]methyl]quinoline-2-carboxamide, CHOLESTEROL, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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5GQ0
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4LVD
| Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1,2-ETHANEDIOL, N-(4-nitrophenyl)cyclopropanecarboxamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. | Deposit date: | 2013-07-26 | Release date: | 2013-09-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
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