1SPS
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1SPR
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1SHA
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1TDF
| CRYSTAL STRUCTURE OF ESCHERICHIA COLI THIOREDOXIN REDUCTASE REFINED AT 2 ANGSTROM RESOLUTION: IMPLICATIONS FOR A LARGE CONFORMATIONAL CHANGE DURING CATALYSIS | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, THIOREDOXIN REDUCTASE | Authors: | Waksman, G, Krishna, T.S.R, Williams Junior, C.H, Kuriyan, J. | Deposit date: | 1994-01-14 | Release date: | 1994-11-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis. J.Mol.Biol., 236, 1994
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1TDE
| CRYSTAL STRUCTURE OF ESCHERICHIA COLI THIOREDOXIN REDUCTASE REFINED AT 2 ANGSTROM RESOLUTION: IMPLICATIONS FOR A LARGE CONFORMATIONAL CHANGE DURING CATALYSIS | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, THIOREDOXIN REDUCTASE | Authors: | Waksman, G, Krishna, T.S.R, Williams Junior, C.H, Kuriyan, J. | Deposit date: | 1994-01-14 | Release date: | 1994-11-30 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis. J.Mol.Biol., 236, 1994
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1SHB
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3U4K
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5FLU
| Structure of a Chaperone-Usher pilus reveals the molecular basis of rod uncoilin | Descriptor: | PAP FIMBRIAL MAJOR PILIN PROTEIN | Authors: | Hospenthal, M.K, Redzej, A, Dodson, K, Ukleja, M, Frenz, B, Hultgren, S.J, DiMaio, F, Egelman, E.H, Waksman, G. | Deposit date: | 2015-10-28 | Release date: | 2016-01-13 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling. Cell(Cambridge,Mass.), 164, 2016
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3KTQ
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1N12
| Crystal structure of the PapE (N-terminal-deleted) pilus subunit bound to a peptide corresponding to the N-terminal extension of the PapK pilus subunit (residues 1-11) from uropathogenic E. coli | Descriptor: | Peptide corresponding to the N-terminal extension of protein PapK, mature Fimbrial protein PapE | Authors: | Sauer, F.G, Pinkner, J.S, Waksman, G, Hultgren, S.J. | Deposit date: | 2002-10-16 | Release date: | 2002-12-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation Cell(Cambridge,Mass.), 111, 2002
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1N0L
| Crystal structure of the PapD chaperone (C-terminally 6x histidine-tagged) bound to the PapE pilus subunit (N-terminal-deleted) from uropathogenic E. coli | Descriptor: | Chaperone protein PapD, mature Fimbrial protein PapE | Authors: | Sauer, F.G, Pinkner, J.S, Waksman, G, Hultgren, S.J. | Deposit date: | 2002-10-14 | Release date: | 2002-12-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation Cell(Cambridge,Mass.), 111, 2002
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7Q1V
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6Y7S
| 2.85 A cryo-EM structure of the in vivo assembled type 1 pilus rod | Descriptor: | Type-1 fimbrial protein, A chain | Authors: | Zyla, D, Hospenthal, M, Waksman, G, Glockshuber, R. | Deposit date: | 2020-03-02 | Release date: | 2021-03-31 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili. Nat Commun, 15, 2024
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6QCM
| Cryo em structure of the Listeria stressosome | Descriptor: | RsbR protein, RsbR protein,RsbR protein, RsbS protein | Authors: | Williams, A.H, Redzej, A, Waksman, G, Cossart, P. | Deposit date: | 2018-12-28 | Release date: | 2019-08-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.21 Å) | Cite: | The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation. Nat Commun, 10, 2019
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8PSV
| 2.7 A cryo-EM structure of in vitro assembled type 1 pilus rod | Descriptor: | Type-1 fimbrial protein, A chain | Authors: | Hospenthal, M, Zyla, D, Glockshuber, R, Waksman, G. | Deposit date: | 2023-07-13 | Release date: | 2024-04-10 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili. Nat Commun, 15, 2024
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8PTU
| 2.5 A cryo-EM structure of the in vitro FimD-catalyzed assembly of type 1 pilus rod | Descriptor: | Type-1 fimbrial protein, A chain | Authors: | Zyla, D, Hospenthal, M, Glockshuber, R, Waksman, G. | Deposit date: | 2023-07-14 | Release date: | 2024-04-10 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili. Nat Commun, 15, 2024
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6GYB
| Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri | Descriptor: | VirB10 protein, VirB7, VirB9 protein | Authors: | Sgro, G.G, Costa, T.R.D, Farah, C.S, Waksman, G. | Deposit date: | 2018-06-28 | Release date: | 2018-10-24 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri. Nat Microbiol, 3, 2018
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5CDW
| Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide | Descriptor: | Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN | Authors: | Papaioannou, D, Geibel, S, Kunze, M, Kay, C, Waksman, G. | Deposit date: | 2015-07-05 | Release date: | 2016-05-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.602 Å) | Cite: | Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. Protein Sci., 25, 2016
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1YMP
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3ZBI
| Fitting result in the O-layer of the subnanometer structure of the bacterial pKM101 type IV secretion system core complex digested with elastase | Descriptor: | TRAF PROTEIN, TRAN PROTEIN, TRAO PROTEIN | Authors: | Rivera-Calzada, A, Fronzes, R, Savva, C.G, Chandran, V, Lian, P.W, Laeremans, T, Pardon, E, Steyaert, J, Remaut, H, Waksman, G, Orlova, E.V. | Deposit date: | 2012-11-10 | Release date: | 2013-04-03 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (8.5 Å) | Cite: | Structure of a Bacterial Type Iv Secretion Core Complex at Subnanometre Resolution. Embo J., 32, 2013
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3Q48
| Crystal structure of Pseudomonas aeruginosa CupB2 chaperone | Descriptor: | Chaperone CupB2 | Authors: | Cai, X, Wang, R, Filloux, A, Waksman, G, Meng, G. | Deposit date: | 2010-12-23 | Release date: | 2011-02-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones Plos One, 6, 2011
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3RFZ
| Crystal structure of the FimD usher bound to its cognate FimC:FimH substrate | Descriptor: | Chaperone protein fimC, Outer membrane usher protein, type 1 fimbrial synthesis, ... | Authors: | Phan, G, Remaut, H, Lebedev, A, Geibel, S, Waksman, G. | Deposit date: | 2011-04-07 | Release date: | 2011-06-01 | Last modified: | 2012-03-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature, 474, 2011
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2YPW
| Atomic model for the N-terminus of TraO fitted in the full-length structure of the bacterial pKM101 type IV secretion system core complex | Descriptor: | TRAO | Authors: | Rivera-Calzada, A, Fronzes, R, Savva, C.G, Chandran, V, Lian, P.W, Laeremans, T, Pardon, E, Steyaert, J, Remaut, H, Waksman, G, Orlova, E.V. | Deposit date: | 2012-11-02 | Release date: | 2013-04-03 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (12.4 Å) | Cite: | Structure of a Bacterial Type Iv Secretion Core Complex at Subnanometre Resolution. Embo J., 32, 2013
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2XG4
| E. coli P pilus chaperone-subunit complex PapD-PapH bound to pilus biogenesis inhibitor, pilicide 2c | Descriptor: | (3R)-8-CYCLOPROPYL-6-(MORPHOLIN-4-YLMETHYL)-7-(1-NAPHTHYLMETHYL)-5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC ACID, CHAPERONE PROTEIN PAPD, COBALT (II) ION, ... | Authors: | Remaut, H, Phan, G, Buelens, F, Chorell, E, Pinkner, J.S, Edvinsson, S, Almqvist, F, Hultgren, S.J, Waksman, G. | Deposit date: | 2010-05-30 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity. J.Med.Chem., 53, 2010
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2XG5
| E. coli P pilus chaperone-subunit complex PapD-PapH bound to pilus biogenesis inhibitor, pilicide 5d | Descriptor: | (2R)-2-[5-CYCLOPROPYL-6-(HYDROXYSULFANYL)-4-(NAPHTHALEN-1-YLMETHYL)-2-OXOPYRIDIN-1(2H)-YL]-3-PHENYLPROPANOIC ACID, (2R,3R)-8-CYCLOPROPYL-7-(NAPHTHALEN-1-YLMETHYL)-5-OXO-2-PHENYL-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC ACID, CHAPERONE PROTEIN PAPD, ... | Authors: | Remaut, H, Phan, G, Buelens, F, Chorell, E, Pinkner, J.S, Edvinsson, S, Almqvist, F, Hultgren, S.J, Waksman, G. | Deposit date: | 2010-05-30 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity. J.Med.Chem., 53, 2010
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