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5ACM
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BU of 5acm by Molmil
Mcg immunoglobulin variable domain with methylene blue
Descriptor: 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, GLYCEROL, MCG, ...
Authors:Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2015-08-17
Release date:2015-12-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.
Elife, 4, 2015
5ACL
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BU of 5acl by Molmil
Mcg immunoglobulin variable domain with sulfasalazine
Descriptor: 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, MCG, SULFATE ION
Authors:Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2015-08-17
Release date:2015-12-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.
Elife, 4, 2015
8FQ7
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BU of 8fq7 by Molmil
Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils
Descriptor: GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils
Authors:Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S.
Deposit date:2023-01-05
Release date:2023-10-04
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc.Natl.Acad.Sci.USA, 120, 2023
7M62
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BU of 7m62 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 2
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
7M65
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BU of 7m65 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 4
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
7M61
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BU of 7m61 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 1
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
7M64
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BU of 7m64 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 3
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
7SP1
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BU of 7sp1 by Molmil
RNA-induced tau amyloid fibril
Descriptor: Isoform Tau-F of Microtubule-associated protein tau, RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3')
Authors:Abskharon, R, Sawaya, M.R, Boyer, D.R, Eisenberg, D.S.
Deposit date:2021-11-02
Release date:2022-03-30
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SXN
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BU of 7sxn by Molmil
Orb2A residues 1-9 MYNKFVNFI
Descriptor: Orb2A residues 1-9 MYNKFVNFI
Authors:Bowler, J.T, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S.
Deposit date:2021-11-23
Release date:2022-10-05
Last modified:2024-05-22
Method:ELECTRON CRYSTALLOGRAPHY (1.05 Å)
Cite:Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like beta-sheets.
J.Biol.Chem., 298, 2022
8TER
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BU of 8ter by Molmil
Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber
Descriptor: TRK-fused gene protein Low Complexity Domain P285L mutant
Authors:Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S.
Deposit date:2023-07-06
Release date:2023-12-20
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method.
Pnas Nexus, 2, 2023
8TEQ
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BU of 8teq by Molmil
Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) G269V mutant, amyloid fiber
Descriptor: TRK-fused gene protein Low Complexity Domain G269V mutant
Authors:Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S.
Deposit date:2023-07-06
Release date:2023-12-20
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method.
Pnas Nexus, 2, 2023
5FOZ
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BU of 5foz by Molmil
De novo structure of the binary mosquito larvicide BinAB at pH 10
Descriptor: LARVICIDAL TOXIN PROTEIN, SODIUM ION, TOXIN
Authors:Colletier, J.P, Sawaya, M.R, Gingery, M, Rodriguez, J.A, Cascio, D, Brewster, A.S, Michels-Clark, T, Boutet, S, Williams, G.J, Messerschmidt, M, DePonte, D.P, Sierra, R.G, Laksmono, H, Koglin, J.E, Hunter, M.S, W Park, H, Uervirojnangkoorn, M, Bideshi, D.L, Brunger, A.T, Federici, B.A, Sauter, N.K, Eisenberg, D.S.
Deposit date:2015-11-26
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure.
Nature, 539, 2016
5G37
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BU of 5g37 by Molmil
MR structure of the binary mosquito larvicide BinAB at pH 5
Descriptor: 41.9 KDA INSECTICIDAL TOXIN, LARVICIDAL TOXIN 51 KDA PROTEIN
Authors:Colletier, J.P, Sawaya, M.R, Gingery, M, Rodriguez, J.A, Cascio, D, Brewster, A.S, Michels-Clark, T, Boutet, S, Williams, G.J, Messerschmidt, M, DePonte, D.P, Sierra, R.G, Laksmono, H, Koglin, J.E, Hunter, M.S, W Park, H, Uervirojnangkoorn, M, Bideshi, D.L, Brunger, A.T, Federici, B.A, Sauter, N.K, Eisenberg, D.S.
Deposit date:2016-04-24
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure.
Nature, 539, 2016
5HGE
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BU of 5hge by Molmil
Filamentous Assembly of Green Fluorescent Protein Supported by a C-terminal fusion of 18-residues, viewed in space group P212121
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Green fluorescent protein
Authors:Sawaya, M.R, Heller, D.M, McPartland, L, Hochschild, A, Eisenberg, D.S.
Deposit date:2016-01-08
Release date:2017-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.863 Å)
Cite:Green Fluorescent Protein Fusion that Self Assembles as Polar Filaments
to be published
5HBD
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BU of 5hbd by Molmil
Filamentous Assembly of Green Fluorescent Protein Supported by a C-terminal fusion of 18-residues, viewed in space group C2
Descriptor: Green fluorescent protein
Authors:Sawaya, M.R, Hochschild, A, Heller, D.M, McPartland, L, Eisenberg, D.S.
Deposit date:2015-12-31
Release date:2017-01-04
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Green Fluorescent Protein Fusion that Self Assembles as Polar Filaments
to be published
5HW9
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BU of 5hw9 by Molmil
Filamentous Assembly of Green Fluorescent Protein Supported by a C-terminal fusion of 18-residues, viewed in space group P21
Descriptor: Green fluorescent protein
Authors:Sawaya, M.R, Heller, D.M, McPartland, L, Hochschild, A, Eisenberg, D.S.
Deposit date:2016-01-29
Release date:2017-02-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Green Fluorescent Protein Fusion that Self Assembles as Polar Filaments
to be published
5FOY
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BU of 5foy by Molmil
De novo structure of the binary mosquito larvicide BinAB at pH 7
Descriptor: 41.9 KDA INSECTICIDAL TOXIN, LARVICIDAL TOXIN 51 KDA PROTEIN
Authors:Colletier, J.P, Sawaya, M.R, Gingery, M, Rodriguez, J.A, Cascio, D, Brewster, A.S, Michels-Clark, T, Boutet, S, Williams, G.J, Messerschmidt, M, DePonte, D.P, Sierra, R.G, Laksmono, H, Koglin, J.E, Hunter, M.S, W Park, H, Uervirojnangkoorn, M, Bideshi, D.L, Brunger, A.T, Federici, B.A, Sauter, N.K, Eisenberg, D.S.
Deposit date:2015-11-26
Release date:2016-10-05
Last modified:2019-08-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure.
Nature, 539, 2016
7ROL
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BU of 7rol by Molmil
Amyloid-related segment of alphaB-crystallin residues 90-100 with G95W mutation, bromo derivative
Descriptor: Alpha-crystallin B chain peptide
Authors:Sawaya, M.R, Do, T.D, Eisenberg, D.S.
Deposit date:2021-07-30
Release date:2022-02-16
Last modified:2022-03-02
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices.
Protein Sci., 31, 2022
5K2H
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BU of 5k2h by Molmil
Structure of GNNQQNY from yeast prion Sup35 in space group P212121 determined by MicroED
Descriptor: Eukaryotic peptide chain release factor GTP-binding subunit
Authors:Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S.
Deposit date:2016-05-18
Release date:2016-09-14
Last modified:2024-03-06
Method:ELECTRON CRYSTALLOGRAPHY (1.05 Å)
Cite:Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.
Proc.Natl.Acad.Sci.USA, 113, 2016
5K2F
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BU of 5k2f by Molmil
Structure of NNQQNY from yeast prion Sup35 with cadmium acetate determined by MicroED
Descriptor: ACETATE ION, CADMIUM ION, Eukaryotic peptide chain release factor GTP-binding subunit
Authors:Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S.
Deposit date:2016-05-18
Release date:2016-09-14
Last modified:2024-03-06
Method:ELECTRON CRYSTALLOGRAPHY (1 Å)
Cite:Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.
Proc.Natl.Acad.Sci.USA, 113, 2016
5K2E
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BU of 5k2e by Molmil
Structure of NNQQNY from yeast prion Sup35 with zinc acetate determined by MicroED
Descriptor: ACETIC ACID, Eukaryotic peptide chain release factor GTP-binding subunit, ZINC ION
Authors:Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S.
Deposit date:2016-05-18
Release date:2016-09-14
Last modified:2024-03-06
Method:ELECTRON CRYSTALLOGRAPHY (1 Å)
Cite:Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.
Proc.Natl.Acad.Sci.USA, 113, 2016
5K2G
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BU of 5k2g by Molmil
Structure of GNNQQNY from yeast prion Sup35 in space group P21 determined by MicroED
Descriptor: Eukaryotic peptide chain release factor GTP-binding subunit
Authors:Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S.
Deposit date:2016-05-18
Release date:2016-09-14
Last modified:2024-03-06
Method:ELECTRON CRYSTALLOGRAPHY (1.1 Å)
Cite:Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.
Proc.Natl.Acad.Sci.USA, 113, 2016
7SAS
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BU of 7sas by Molmil
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-09-23
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
7SAQ
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BU of 7saq by Molmil
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-09-23
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
7SAR
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BU of 7sar by Molmil
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-09-23
Release date:2022-03-09
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022

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