8TEQ

Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) G269V mutant, amyloid fiber

Summary for 8TEQ

Entry DOI	10.2210/pdb8teq/pdb
EMDB information	41195
Descriptor	TRK-fused gene protein Low Complexity Domain G269V mutant (1 entity in total)
Functional Keywords	amyloid, mutation, charcot-marie-tooth disease, hereditary motor and sensory neuropathy with proximal dominant involvement, protein fibril
Biological source	Purpureocillium lilacinum More
Total number of polymer chains	30
Total formula weight	1214723.67
Authors	Rosenberg, G.M.,Sawaya, M.R.,Boyer, D.R.,Ge, P.,Abskharon, R.,Eisenberg, D.S. (deposition date: 2023-07-06, release date: 2023-12-20, Last modification date: 2023-12-27)
Primary citation	Rosenberg, G.M.,Abskharon, R.,Boyer, D.R.,Ge, P.,Sawaya, M.R.,Eisenberg, D.S. Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. Pnas Nexus, 2:pgad402-pgad402, 2023 Cited by PubMed: 38077690 DOI: 10.1093/pnasnexus/pgad402 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.84 Å)

Structure validation