8TER
Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber
Summary for 8TER
Entry DOI | 10.2210/pdb8ter/pdb |
Related | 8TEQ |
EMDB information | 41198 |
Descriptor | TRK-fused gene protein Low Complexity Domain P285L mutant (2 entities in total) |
Functional Keywords | amyloid, mutation, charcot-marie-tooth disease, hereditary motor and sensory neuropathy with proximal dominant involvement, protein fibril |
Biological source | Purpureocillium lilacinum More |
Total number of polymer chains | 20 |
Total formula weight | 809295.08 |
Authors | Rosenberg, G.M.,Sawaya, M.R.,Boyer, D.R.,Ge, P.,Abskharon, R.,Eisenberg, D.S. (deposition date: 2023-07-06, release date: 2023-12-20, Last modification date: 2023-12-27) |
Primary citation | Rosenberg, G.M.,Abskharon, R.,Boyer, D.R.,Ge, P.,Sawaya, M.R.,Eisenberg, D.S. Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. Pnas Nexus, 2:pgad402-pgad402, 2023 Cited by PubMed: 38077690DOI: 10.1093/pnasnexus/pgad402 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.59 Å) |
Structure validation
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