8TGO

Crystal structure of the BG505 triple tandem trimer gp140 HIV-1 Env in complex with PGT124 and 35O22

This is a non-PDB format compatible entry.

Summary for 8TGO

• Entry DOI: 10.2210/pdb8tgo/pdb
• Descriptor: Envelope glycoprotein gp41, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: hiv, envelope, antibody, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 15
• Total formula weight: 476175.39

Authors

Xian, Y.,Yuan, M.,Wilson, I.A. (deposition date: 2023-07-12, release date: 2024-04-17)

• Primary citation: Del Moral-Sanchez, I.,Wee, E.G.,Xian, Y.,Lee, W.H.,Allen, J.D.,Torrents de la Pena, A.,Froes Rocha, R.,Ferguson, J.,Leon, A.N.,Koekkoek, S.,Schermer, E.E.,Burger, J.A.,Kumar, S.,Zwolsman, R.,Brinkkemper, M.,Aartse, A.,Eggink, D.,Han, J.,Yuan, M.,Crispin, M.,Ozorowski, G.,Ward, A.B.,Wilson, I.A.,Hanke, T.,Sliepen, K.,Sanders, R.W.; Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines.; Npj Vaccines, 9:74-74, 2024; PubMed: 38582771; DOI: 10.1038/s41541-024-00862-8

Experimental method

X-RAY DIFFRACTION (5.75 Å)