8TGO
Crystal structure of the BG505 triple tandem trimer gp140 HIV-1 Env in complex with PGT124 and 35O22
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, H, a | Envelope glycoprotein gp41 | polymer | 164 | 17856.0 | 3 | UniProt (Q2N0S6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | |
2 | D, L, b | 35O22 scFv | polymer | 286 | 30339.3 | 3 | Homo sapiens (human) | ||
3 | C, P, c | PGT124 light chain | polymer | 214 | 23056.6 | 3 | Homo sapiens (human) | ||
4 | G, R, e | Envelope glycoprotein gp120 | polymer | 490 | 54164.1 | 3 | UniProt (Q2N0S6) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
5 | O, S, f | PGT124 heavy chain | polymer | 235 | 25345.4 | 3 | Homo sapiens (human) | ||
6 | A | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
7 | X, g, h, j, l... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 14 | In PDB GlyTouCan (G42666HT) | |||
8 | Y, Z, m, n, I... | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 6 | In PDB GlyTouCan (G15407YE) | |||
9 | i, q, N | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 3 | In PDB GlyTouCan (G40702WU) | |||
10 | k, V | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
11 | H, R, a, e, B... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 31 | Chemie (NAG) |
Sequence modifications
B, H, a: 512 - 664 (UniProt: Q2N0S6)
G, R, e: 31 - 507 (UniProt: Q2N0S6)
PDB | External Database | Details |
---|---|---|
Ser 519 | Phe 516 | conflict |
Pro 559 | Ile 556 | conflict |
Asp 568 | Leu 565 | conflict |
His 570 | Val 567 | conflict |
His 585 | Arg 582 | conflict |
Cys 605 | Thr 602 | conflict |
Gly 665 | - | expression tag |
Ser 666 | - | expression tag |
Gly 667 | - | expression tag |
Gly 668 | - | expression tag |
Ser 669 | - | expression tag |
Gly 670 | - | expression tag |
Gly 671 | - | expression tag |
Ser 672 | - | expression tag |
Gly 673 | - | expression tag |
Ser 674 | - | expression tag |
Gly 675 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Lys 64 | Glu 63 | conflict |
Glu 106 | Thr 105 | conflict |
Ile 271 | Met 270 | conflict |
Leu 288 | Phe 287 | conflict |
Val 304 | Arg 303 | conflict |
Trp 316 | Ala 313 | conflict |
Tyr 319 | Ala 316 | conflict |
Asn 332 | Thr 330 | conflict |
Lys 500 | Arg 497 | conflict |
Cys 501 | Ala 498 | conflict |
Gly 508 | - | expression tag |
Gly 509 | - | expression tag |
Ser 510 | - | expression tag |
Gly 511 | - | expression tag |
Gly 512 | - | expression tag |
Gly 513 | - | expression tag |
Gly 514 | - | expression tag |
Ser 515 | - | expression tag |
Gly 516 | - | expression tag |
Gly 517 | - | expression tag |
Gly 518 | - | expression tag |
Gly 519 | - | expression tag |
Ser 520 | - | expression tag |
Gly 521 | - | expression tag |
Gly 522 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 15 |
Total formula weight | 452284.3 | |
Branched | Number of molecules | 26 |
Total formula weight | 17033.6 | |
Non-Polymers* | Number of molecules | 31 |
Total formula weight | 6857.4 | |
All* | Total formula weight | 476175.4 |