8SI4

Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in open state

Summary for 8SI4

• Entry DOI: 10.2210/pdb8si4/pdb
• Related: 8SI2 8SI3
• EMDB information: 40496 40497 40498
• Descriptor: Transient receptor potential cation channel subfamily M member 7, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, ... (6 entities in total)
• Functional Keywords: transient receptor potential m family member 7, trp, channel, trpm7, trp channels, membrane protein, magnesium channel, n1098q, open state
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 4
• Total formula weight: 632856.23

Authors

Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-04-14, release date: 2023-05-17, Last modification date: 2023-05-24)

• Primary citation: Nadezhdin, K.D.,Correia, L.,Narangoda, C.,Patel, D.S.,Neuberger, A.,Gudermann, T.,Kurnikova, M.G.,Chubanov, V.,Sobolevsky, A.I.; Structural mechanisms of TRPM7 activation and inhibition.; Nat Commun, 14:2639-2639, 2023; PubMed: 37156763; DOI: 10.1038/s41467-023-38362-3

Experimental method

ELECTRON MICROSCOPY (2.46 Å)