8RRQ

Crystal structure of human SYK in complex with compound 24

This is a non-PDB format compatible entry.

Summary for 8RRQ

• Entry DOI: 10.2210/pdb8rrq/pdb
• Descriptor: Tyrosine-protein kinase SYK, N-[(1S,2R)-2-azanylcyclohexyl]-5-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-2-methyl-pyrazole-3-carboxamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: inhibitor, kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 33379.28

Authors

Canevari, G. (deposition date: 2024-01-23, release date: 2024-04-24)

• Primary citation: Cervi, G.,D'Alessio, R.,Bindi, S.,Buffa, L.,Burocchi, A.,Canevari, G.,Modugno, M.,Motto, I.,Saturno, G.,Orsini, P.; Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors.; Eur.J.Med.Chem., 270:116375-116375, 2024; PubMed: 38604095; DOI: 10.1016/j.ejmech.2024.116375

Experimental method

X-RAY DIFFRACTION (1.6 Å)