8QYU

Beta-cardiac myosin S1 fragment in the pre-powerstroke state complexed to Omecamtiv mecarbil

Summary for 8QYU

Entry DOI	10.2210/pdb8qyu/pdb
Descriptor	Myosin-7, MALONIC ACID, Myosin light chain 3, ... (11 entities in total)
Functional Keywords	cardiac myosin modulators inherited cardiomyopathies omecamtiv mecarbil, contractile protein
Biological source	Bos taurus (cattle) More
Total number of polymer chains	4
Total formula weight	231996.96
Authors	Robert-Paganin, J.,Kikuti, C.,Auguin, D.,Rety, S.,David, A.,Houdusse, A. (deposition date: 2023-10-26, release date: 2023-12-13)
Primary citation	Auguin, D.,Robert-Paganin, J.,Rety, S.,Kikuti, C.,David, A.,Theumer, G.,Schmidt, A.W.,Knolker, H.J.,Houdusse, A. Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction. Biorxiv, 2023 Cited by PubMed: 38014327 DOI: 10.1101/2023.11.15.567213 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation