8PMO
Crystal structure of human V122I transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder)
Summary for 8PMO
| Entry DOI | 10.2210/pdb8pmo/pdb |
| Descriptor | Transthyretin, (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone (3 entities in total) |
| Functional Keywords | aggregation, amyloid, t4 hormone binding, protein transport |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 28197.24 |
| Authors | Varejao, N.,Pinheiro, F.,Pallares, I.,Ventura, S.,Reverter, D. (deposition date: 2023-06-29, release date: 2024-05-08) |
| Primary citation | Pinheiro, F.,Varejao, N.,Sanchez-Morales, A.,Bezerra, F.,Navarro, S.,Velazquez-Campoy, A.,Busque, F.,Almeida, M.R.,Alibes, R.,Reverter, D.,Pallares, I.,Ventura, S. PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur.J.Med.Chem., 261:115837-115837, 2023 Cited by PubMed: 37837673DOI: 10.1016/j.ejmech.2023.115837 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.24 Å) |
Structure validation
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