8PMO
Crystal structure of human V122I transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Transthyretin | polymer | 127 | 13791.4 | 2 | UniProt (P02766) Pfam (PF00576) In PDB | Homo sapiens (human) | ATTR,Prealbumin,TBPA |
| 2 | A, B | (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone | non-polymer | 307.2 | 2 | Chemie (ZP2) | |||
| 3 | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 127 (UniProt: P02766)
| PDB | External Database | Details |
|---|---|---|
| Ile 122 | Val 142 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27582.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 614.5 | |
| All* | Total formula weight | 28197.2 |
