8OPN

Human Coronavirus HKU1 spike glycoprotein in complex with an alpha2,8-linked 9-O-acetylated disialoside (1-up state)

Summary for 8OPN

• Entry DOI: 10.2210/pdb8opn/pdb
• Related: 8OHN 8OPM 8OPO
• EMDB information: 17077
• Descriptor: Spike glycoprotein,General control transcription factor GCN4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 9-O-acetyl-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosonic acid-(2-8)-N-acetyl-alpha-neuraminic acid, ... (4 entities in total)
• Functional Keywords: virus, coronavirus, hku1, spike, glycoprotein, membrane fusion, viral protein
• Biological source: Human coronavirus HKU1; More
• Total number of polymer chains: 3
• Total formula weight: 452687.73

Authors

Pronker, M.F.,Creutznacher, R.,Hurdiss, D.L. (deposition date: 2023-04-07, release date: 2023-08-02, Last modification date: 2023-12-13)

• Primary citation: Pronker, M.F.,Creutznacher, R.,Drulyte, I.,Hulswit, R.J.G.,Li, Z.,van Kuppeveld, F.J.M.,Snijder, J.,Lang, Y.,Bosch, B.J.,Boons, G.J.,Frank, M.,de Groot, R.J.,Hurdiss, D.L.; Sialoglycan binding triggers spike opening in a human coronavirus.; Nature, 624:201-206, 2023; PubMed: 37794193; DOI: 10.1038/s41586-023-06599-z

Experimental method

ELECTRON MICROSCOPY (4.7 Å)