8OO5

Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 13

Summary for 8OO5

• Entry DOI: 10.2210/pdb8oo5/pdb
• Descriptor: DDB1- and CUL4-associated factor 1, 1-[4-[4-(2-azanylethylamino)-2-[1-(4-chlorophenyl)cyclohexyl]quinazolin-7-yl]piperazin-1-yl]ethanone, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: dcaf1, ligase, compound, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 37324.97

Authors

Schroeder, M.,Renatus, M. (deposition date: 2023-04-04, release date: 2023-05-24)

• Primary citation: Schroder, M.,Renatus, M.,Thoma, C.R.; Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings; Biorxiv, 2023; DOI: 10.1101/2023.04.09.536153

Experimental method

X-RAY DIFFRACTION (2.25 Å)