8I2G

FSHR-Follicle stimulating hormone-compound 716340-Gs complex

Summary for 8I2G

• Entry DOI: 10.2210/pdb8i2g/pdb
• EMDB information: 35135
• Descriptor: chimera of Guanine nucleotide-binding protein G(s) subunit alpha and Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, PALMITIC ACID, MYRISTIC ACID, ... (13 entities in total)
• Functional Keywords: follicle stimulating hormone, fsh, gpcr, gs-protein, hormone
• Biological source: Cricetulus griseus (Chinese hamster); More
• Total number of polymer chains: 7
• Total formula weight: 196969.02

Authors

Duan, J.,Xu, P.,Yang, J.,Ji, Y.,Zhang, H.,Mao, C.,Luan, X.,Jiang, Y.,Zhang, Y.,Zhang, S.,Xu, H.E. (deposition date: 2023-01-14, release date: 2023-03-29, Last modification date: 2023-04-05)

• Primary citation: Duan, J.,Xu, P.,Zhang, H.,Luan, X.,Yang, J.,He, X.,Mao, C.,Shen, D.D.,Ji, Y.,Cheng, X.,Jiang, H.,Jiang, Y.,Zhang, S.,Zhang, Y.,Xu, H.E.; Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor.; Nat Commun, 14:519-519, 2023; PubMed: 36720854; DOI: 10.1038/s41467-023-36170-3

Experimental method

ELECTRON MICROSCOPY (2.8 Å)