8I2G
FSHR-Follicle stimulating hormone-compound 716340-Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | chimera of Guanine nucleotide-binding protein G(s) subunit alpha and Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | polymer | 259 | 30168.2 | 1 | UniProt (Q8R4A8) UniProt (Q5JWF2) Pfam (PF00503) In PDB | Cricetulus griseus (Chinese hamster) | Adenylate cyclase-stimulating G alpha protein,Adenylate cyclase-stimulating G alpha protein,Extra large alphas protein,XLalphas |
| 2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
| 4 | N | Nb35 | polymer | 128 | 13885.4 | 1 | Lama glama | ||
| 5 | R | Follicle-stimulating hormone receptor | polymer | 678 | 76683.7 | 1 | UniProt (P23945) Pfam (PF01462) Pfam (PF13306) Pfam (PF12369) Pfam (PF00001) In PDB | Homo sapiens (human) | FSH-R,Follitropin receptor |
| 6 | X | Glycoprotein hormones alpha chain | polymer | 92 | 10183.8 | 1 | UniProt (P01215) Pfam (PF00236) In PDB | Homo sapiens (human) | Anterior pituitary glycoprotein hormones common subunit alpha,Choriogonadotropin alpha chain,Chorionic gonadotrophin subunit alpha,CG-alpha,Follicle-stimulating hormone alpha chain,FSH-alpha,Follitropin alpha chain,Luteinizing hormone alpha chain,LSH-alpha,Lutropin alpha chain,Thyroid-stimulating hormone alpha chain,TSH-alpha,Thyrotropin alpha chain |
| 7 | Y | Follitropin subunit beta | polymer | 109 | 12241.9 | 1 | UniProt (P01225) Pfam (PF00007) In PDB | Homo sapiens (human) | Follicle-stimulating hormone beta subunit,FSH-B,FSH-beta,Follitropin beta chain |
| 8 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 9 | R | CHOLESTEROL | non-polymer | 386.7 | 13 | Chemie (CLR) | |||
| 10 | R | PALMITIC ACID | non-polymer | 256.4 | 3 | Chemie (PLM) | |||
| 11 | R | MYRISTIC ACID | non-polymer | 228.4 | 2 | Chemie (MYR) | |||
| 12 | X, Y, R | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 13 | R | N-tert-butyl-N-ethyl-8-methoxy-9-propan-2-yloxy-1-thiophen-2-yl-5,6-dihydroimidazo[5,1-a]isoquinoline-3-carboxamide | non-polymer | 467.6 | 1 | Chemie (O6F) |
Sequence modifications
A: 6 - 195 (UniProt: Q8R4A8)
A: 205 - 394 (UniProt: Q5JWF2)
B: 2 - 340 (UniProt: P62873)
R: 18 - 695 (UniProt: P23945)
X: 1 - 92 (UniProt: P01215)
| PDB | External Database | Details |
|---|---|---|
| Met 5 | - | initiating methionine |
| Gly 196 | - | linker |
| Gly 197 | - | linker |
| Ser 198 | - | linker |
| Gly 199 | - | linker |
| Gly 200 | - | linker |
| Ser 201 | - | linker |
| Gly 202 | - | linker |
| Gly 203 | - | linker |
| Thr 204 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Thr 205 | Ser 848 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ile 273 | Ser 273 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Leu 17 | Phe 41 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 188939.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 7605.0 | |
| All* | Total formula weight | 196969.0 |
