8GWR
Near full length Kidney type Glutaminase in complex with 2,2-Dimethyl-2,3-Dihydrobenzo[a] Phenanthridin-4(1H)-one (DDP)
Summary for 8GWR
| Entry DOI | 10.2210/pdb8gwr/pdb |
| Descriptor | Glutaminase kidney isoform, mitochondrial, 2,2-dimethyl-1,3-dihydrobenzo[a]phenanthridin-4-one (3 entities in total) |
| Functional Keywords | glutaminase, complex, allosteric inhibition, small molecule inhibitor, cancer, oncoprotein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 147383.33 |
| Authors | Shankar, S.,Jobichen, C.,Sivaraman, J. (deposition date: 2022-09-17, release date: 2022-12-21, Last modification date: 2023-11-29) |
| Primary citation | Shankar, S.,Ramachandran, S.,Tulsian, N.,Radhakrishnan, S.,Jobichen, C.,Sivaraman, J. A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase. Febs J., 290:2437-2448, 2023 Cited by PubMed: 36259273DOI: 10.1111/febs.16658 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.801 Å) |
Structure validation
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