8GWR

Near full length Kidney type Glutaminase in complex with 2,2-Dimethyl-2,3-Dihydrobenzo[a] Phenanthridin-4(1H)-one (DDP)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001967	biological_process	suckling behavior
A	0002087	biological_process	regulation of respiratory gaseous exchange by nervous system process
A	0004359	molecular_function	glutaminase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006537	biological_process	glutamate biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0006543	biological_process	glutamine catabolic process
A	0007268	biological_process	chemical synaptic transmission
A	0016787	molecular_function	hydrolase activity
A	0045202	cellular_component	synapse
A	0051289	biological_process	protein homotetramerization
A	0090461	biological_process	intracellular glutamate homeostasis
B	0001967	biological_process	suckling behavior
B	0002087	biological_process	regulation of respiratory gaseous exchange by nervous system process
B	0004359	molecular_function	glutaminase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006537	biological_process	glutamate biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0006543	biological_process	glutamine catabolic process
B	0007268	biological_process	chemical synaptic transmission
B	0016787	molecular_function	hydrolase activity
B	0045202	cellular_component	synapse
B	0051289	biological_process	protein homotetramerization
B	0090461	biological_process	intracellular glutamate homeostasis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1

Chain	Residue	Details
B	SER286
A	TYR414
A	TYR466
A	VAL484
B	ASN335
B	GLU381
B	TYR414
B	TYR466
B	VAL484
A	SER286
A	ASN335
A	GLU381

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP1

Chain	Residue	Details
B	ASN388
A	ASN388

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by MPP => ECO:0000250|UniProtKB:P13264

Chain	Residue	Details
B	LEU72
A	LEU72

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:D3Z7P3

Chain	Residue	Details
B	LYS130
B	LYS164
A	LYS130
A	LYS164

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS311
A	LYS311

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P13264

Chain	Residue	Details
B	SER652
A	SER652

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