8GFA

Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791

Summary for 8GFA

Entry DOI	10.2210/pdb8gfa/pdb
Related	8GF8 8GF9
EMDB information	29981 29982 29983
Descriptor	Transient receptor potential cation channel subfamily V member 1, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide, ... (6 entities in total)
Functional Keywords	transient receptor potential v family member 1, trp, human, channel, inhibition, antagonist, trpv1, trp channels, pain, analgesic, drug, membrane protein, sb-366791, thermo-trp, temperature sensation, vanilloid, gdn, detergent, glyco-diosgenin
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	528927.81
Authors	Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2023-03-07, release date: 2023-05-10)
Primary citation	Neuberger, A.,Oda, M.,Nikolaev, Y.A.,Nadezhdin, K.D.,Gracheva, E.O.,Bagriantsev, S.N.,Sobolevsky, A.I. Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14:2451-2451, 2023 Cited by PubMed: 37117175 DOI: 10.1038/s41467-023-38162-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.29 Å)

Structure validation