8GF8

Cryo-EM structure of human TRPV1 in cNW11 nanodisc and soybean lipids

Summary for 8GF8

Entry DOI	10.2210/pdb8gf8/pdb
Related	8GF9 8GFA
EMDB information	29981 29982 29983
Descriptor	Transient receptor potential cation channel subfamily V member 1, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, ... (4 entities in total)
Functional Keywords	transient receptor potential v family member 1, vanilloid, trp, apo, human, channel, trpv1, trp channels, pain, membrane protein, cnw11, nanodiscs, thermo-trp, temperature sensation
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	529178.39
Authors	Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2023-03-07, release date: 2023-05-10)
Primary citation	Neuberger, A.,Oda, M.,Nikolaev, Y.A.,Nadezhdin, K.D.,Gracheva, E.O.,Bagriantsev, S.N.,Sobolevsky, A.I. Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14:2451-2451, 2023 Cited by PubMed: 37117175 DOI: 10.1038/s41467-023-38162-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation