8GCK
Crystal structure of the human CHIP-TPR domain in complex with a 6mer acetylated tau peptide
Summary for 8GCK
Entry DOI | 10.2210/pdb8gck/pdb |
Related | 8FYU |
Descriptor | E3 ubiquitin-protein ligase CHIP, ACE-SER-ILE-ASP-MET-VAL-ASP (3 entities in total) |
Functional Keywords | e3 ligase, ligand, tpr domain, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 30741.01 |
Authors | Wucherer, K.,Bohn, M.F.,Basu, K.,Nadel, C.M.,Gestwicki, J.E.,Craik, C.S. (deposition date: 2023-03-02, release date: 2024-03-06) |
Primary citation | Nadel, C.M.,Wucherer, K.N.,Thwin, A.,Southworth, D.,Gestwicki, J.E. Intersecting PTMs regulate clearance of pathogenic tau by the ubiquitin ligase CHIP. To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.36823537069 Å) |
Structure validation
Download full validation report