8FYU

Crystal structure of the human CHIP-TPR domain in complex with a 10mer acetylated tau peptide

Summary for 8FYU

Entry DOI	10.2210/pdb8fyu/pdb
Descriptor	E3 ubiquitin-protein ligase CHIP, ACE-SER-SER-THR-GLY-SER-ILE-ASP-MET-VAL-ASP (3 entities in total)
Functional Keywords	e3 ligase, ligand, tpr domain, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	31353.56
Authors	Wucherer, K.,Bohn, M.F.,Basu, K.,Nadel, C.M.,Gestwicki, J.E.,Craik, C.S. (deposition date: 2023-01-26, release date: 2023-08-30, Last modification date: 2023-09-13)
Primary citation	Nadel, C.M.,Wucherer, K.,Oehler, A.,Thwin, A.C.,Basu, K.,Callahan, M.D.,Southworth, D.R.,Mordes, D.A.,Craik, C.S.,Gestwicki, J.E. Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP. Biorxiv, 2023 Cited by PubMed: 37645969 DOI: 10.1101/2023.08.16.553575 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84839139202 Å)

Structure validation