8G5F
Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA and allopregnanolone
This is a non-PDB format compatible entry.
Summary for 8G5F
| Entry DOI | 10.2210/pdb8g5f/pdb |
| EMDB information | 29741 |
| Descriptor | Gamma-aminobutyric acid receptor subunit alpha-3, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, allopregnanolone, ... (12 entities in total) |
| Functional Keywords | ligand-gated ion channel, cys-loop receptor, neurotransmitter receptor, membrane protein |
| Biological source | Mus musculus (house mouse) More |
| Total number of polymer chains | 7 |
| Total formula weight | 335505.51 |
| Authors | Sun, C.,Gouaux, E. (deposition date: 2023-02-13, release date: 2023-09-20, Last modification date: 2023-11-15) |
| Primary citation | Sun, C.,Zhu, H.,Clark, S.,Gouaux, E. Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622:195-201, 2023 Cited by PubMed: 37730991DOI: 10.1038/s41586-023-06556-w PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.64 Å) |
Structure validation
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