8G5F

Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA and allopregnanolone

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0004890	molecular_function	GABA-A receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0007214	biological_process	gamma-aminobutyric acid signaling pathway
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0004890	molecular_function	GABA-A receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0004890	molecular_function	GABA-A receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006821	biological_process	chloride transport
C	0007214	biological_process	gamma-aminobutyric acid signaling pathway
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0004890	molecular_function	GABA-A receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006821	biological_process	chloride transport
D	0007214	biological_process	gamma-aminobutyric acid signaling pathway
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0004890	molecular_function	GABA-A receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
K	TYR191-HIS197

---

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CqLqLhnFPmDehsC

Chain	Residue	Details
D	CYS151-CYS165
A	CYS163-CYS177
B	CYS136-CYS150
C	CYS138-CYS152

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	233
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
D	GLN1-GLY234
E	SER2-TYR220

---

site_id	SWS_FT_FI2
Number of Residues	89
Details	TRANSMEM: Helical => ECO:0000305

Chain	Residue	Details
D	TYR235-ILE257
D	ALA261-ALA283
D	ALA295-LEU317
D	TYR413-LEU436
E	PHE221-ILE242
E	ALA246-LEU268
E	ALA280-VAL302
E	TRP466-VAL487

---

site_id	SWS_FT_FI3
Number of Residues	94
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
D	HIS318-SER412
E	ASN303-ARG465

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000305

Chain	Residue	Details
D	SER343
C	ASN110
A	SER414

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
D	ASN13
D	ASN90
D	ASN208
E	ASN8
E	ASN80
E	ASN149

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN35
A	ASN135
A	ASN148
A	ASN200

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