8FX3

Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Immucillin-GP, showing the structure of the complete active site in its open conformation

Summary for 8FX3

Entry DOI	10.2210/pdb8fx3/pdb
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, PHOSPHORIC ACID MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL] ESTER (3 entities in total)
Functional Keywords	hypoxanthine-guanine-xanthine phosphoribosyltransferase, inhibitor, hgxprt, transferase-inhibitor complex, transferase/inhibitor
Biological source	Trypanosoma cruzi (strain CL Brener)
Total number of polymer chains	2
Total formula weight	52488.46
Authors	Hughes, R.,Meneely, K.M.,Glockzin, K.,Suthagar, K.,Tyler, P.C.,Lamb, A.L.,Meek, T.D.,Katzfuss, A. (deposition date: 2023-01-23, release date: 2023-07-19, Last modification date: 2023-11-22)
Primary citation	Glockzin, K.,Meneely, K.M.,Hughes, R.,Maatouk, S.W.,Pina, G.E.,Suthagar, K.,Clinch, K.,Buckler, J.N.,Lamb, A.L.,Tyler, P.C.,Meek, T.D.,Katzfuss, A. Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors. Biochemistry, 62:2182-2201, 2023 Cited by PubMed: 37418678 DOI: 10.1021/acs.biochem.3c00116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.31 Å)

Structure validation