8DO1
Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin F
Summary for 8DO1
| Entry DOI | 10.2210/pdb8do1/pdb |
| EMDB information | 27587 |
| Descriptor | Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit gamma, Protein transport protein Sec61 subunit beta, ... (5 entities in total) |
| Functional Keywords | translocon, inhibitor, protein translocation, protein transport, protein transport-inhibitor complex, protein transport/inhibitor |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 70773.17 |
| Authors | Park, E.,Itskanov, S. (deposition date: 2022-07-12, release date: 2023-05-24, Last modification date: 2023-09-06) |
| Primary citation | Itskanov, S.,Wang, L.,Junne, T.,Sherriff, R.,Xiao, L.,Blanchard, N.,Shi, W.Q.,Forsyth, C.,Hoepfner, D.,Spiess, M.,Park, E. A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19:1063-1071, 2023 Cited by PubMed: 37169959DOI: 10.1038/s41589-023-01337-y PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.01 Å) |
Structure validation
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