8DFN
Crystal Structure of SARS-CoV-2 Main Protease (Mpro) H164N Mutant
Summary for 8DFN
Entry DOI | 10.2210/pdb8dfn/pdb |
Related | 84DJ 84DK 8D4L 8D4M 8D4N 8DCZ 8DD1 |
Descriptor | 3C-like proteinase nsp5 (2 entities in total) |
Functional Keywords | protease, sars-cov-2, mpro, mutation, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 2 |
Total formula weight | 67603.00 |
Authors | Lewandowski, E.M.,Butler, S.G.,Hu, Y.,Tan, H.,Wang, J.,Chen, Y. (deposition date: 2022-06-22, release date: 2022-07-13, Last modification date: 2023-10-25) |
Primary citation | Hu, Y.,Lewandowski, E.M.,Tan, H.,Zhang, X.,Morgan, R.T.,Zhang, X.,Jacobs, L.M.C.,Butler, S.G.,Gongora, M.V.,Choy, J.,Deng, X.,Chen, Y.,Wang, J. Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9:1658-1669, 2023 Cited by PubMed: 37637734DOI: 10.1021/acscentsci.3c00538 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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