8DD1

SARS-CoV-2 Main Protease (Mpro) H164N Mutant in Complex with Inhibitor GC376

Summary for 8DD1

Entry DOI	10.2210/pdb8dd1/pdb
Related	8D4J 8D4K 8D4L 8D4M 8D4N
Related PRD ID	PRD_002495
Descriptor	3C-like proteinase nsp5, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total)
Functional Keywords	protease, sars-cov-2, mpro, mutation, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	1
Total formula weight	34287.05
Authors	Lewandowski, E.M.,Butler, S.G.,Hu, Y.,Tan, H.,Wang, J.,Chen, Y. (deposition date: 2022-06-17, release date: 2022-07-13, Last modification date: 2023-10-25)
Primary citation	Hu, Y.,Lewandowski, E.M.,Tan, H.,Zhang, X.,Morgan, R.T.,Zhang, X.,Jacobs, L.M.C.,Butler, S.G.,Gongora, M.V.,Choy, J.,Deng, X.,Chen, Y.,Wang, J. Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9:1658-1669, 2023 Cited by PubMed: 37637734 DOI: 10.1021/acscentsci.3c00538 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation