8D4J

Crystal Structure of SARS-CoV-2 Main Protease (Mpro) H172Y Mutant

Summary for 8D4J

Entry DOI	10.2210/pdb8d4j/pdb
Related	8D4K 8D4L 8D4M 8D4N
Descriptor	3C-like proteinase nsp5, GLYCEROL (3 entities in total)
Functional Keywords	protease, sars-cov-2, mpro, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
Total number of polymer chains	2
Total formula weight	67793.24
Authors	Lewandowski, E.M.,Hu, Y.,Tan, H.,Wang, J.,Chen, Y. (deposition date: 2022-06-02, release date: 2022-07-13, Last modification date: 2023-10-18)
Primary citation	Hu, Y.,Lewandowski, E.M.,Tan, H.,Zhang, X.,Morgan, R.T.,Zhang, X.,Jacobs, L.M.C.,Butler, S.G.,Gongora, M.V.,Choy, J.,Deng, X.,Chen, Y.,Wang, J. Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. Biorxiv, 2022 Cited by PubMed: 36119652 DOI: 10.1101/2022.06.28.497978 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation