8DFE
Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144L Mutant
Summary for 8DFE
| Entry DOI | 10.2210/pdb8dfe/pdb |
| Descriptor | 3C-like proteinase nsp5 (2 entities in total) |
| Functional Keywords | protease, sars-cov-2, mpro, viral protein |
| Biological source | Severe acute respiratory syndrome coronavirus 2 |
| Total number of polymer chains | 1 |
| Total formula weight | 33851.63 |
| Authors | Lewandowski, E.M.,Jacobs, L.M.C.,Hu, Y.,Tan, H.,Wang, J.,Chen, Y. (deposition date: 2022-06-22, release date: 2022-07-13, Last modification date: 2023-10-25) |
| Primary citation | Hu, Y.,Lewandowski, E.M.,Tan, H.,Zhang, X.,Morgan, R.T.,Zhang, X.,Jacobs, L.M.C.,Butler, S.G.,Gongora, M.V.,Choy, J.,Deng, X.,Chen, Y.,Wang, J. Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9:1658-1669, 2023 Cited by PubMed: 37637734DOI: 10.1021/acscentsci.3c00538 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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